Smokeless tobacco damages DNA, key enzymesJune 17th, 2010 - 2:58 pm ICT by ANI
Washington, June 17 (ANI): Smokeless tobacco’s adverse effects are not just limited to the mouth, it can also damage the normal function of a key family of enzymes found in almost every organ in the body, according to a new research.
The enzymes play important roles in production of hormones, including
the sex hormones estrogen and testosterone; production of cholesterol and vitamin D; and help the body breakdown prescription drugs and potentially toxic substances.
Smokeless tobacco also damages genetic material in the liver, kidney and lungs.
Krishan Khanduja and colleagues note widespread recognition of smokeless tobacco’s harmful effects on the mouth, which include an increased risk of gum disease and oral cancer.
The potential carcinogens and other chemicals in chewing tobacco and other smokeless products are absorbed into the blood and travel throughout the body.
However, scientists have little information on smokeless tobacco’s effects on other parts of the body.
To fill that knowledge gap, the scientists evaluated changes in enzymes and genetic material in laboratory rats using extracts of smokeless tobacco.
In addition to damage to the genetic material DNA, they found that smokeless tobacco extracts alter the function of the so-called CYP-450 family of enzymes.
“These products are used around the world but are most common in Northern Africa, Southeast Asia, and the Mediterranean region,” the study says.
“Most of the users seem to be unaware of the harmful health effects and, therefore, use smokeless tobacco to ‘treat’ toothaches, headaches, and stomachaches. This false impression only promotes tobacco use among youth. The use of smokeless tobacco and its new products is increasing not only among men but also among children, teenagers, women, and immigrants of South Asian origin and medical and dental students,” the study adds.
The study has been published in ACS’ monthly journal Chemical Research in Toxicology. (ANI)
- New carcinogen in smokeless tobacco identified - Apr 27, 2012
- How cigarette smoke affects smokers - Apr 07, 2011
- Smokeless tobacco products not safe: Study - Sep 14, 2010
- Smokeless cigarettes less harmful - Feb 21, 2012
- New targeted drug could aid in smoking reduction therapy - Mar 18, 2011
- After cigarettes, health ministry targets other tobacco - Apr 04, 2011
- After cigarettes, health ministry targets other tobacco (Lead) - Apr 04, 2011
- Male foetuses more vulnerable to alcohol - Mar 24, 2011
- Now, a flourescent fish to track pollution - Apr 19, 2012
- Harsher pictorial warnings on tobacco packs from Dec 1 (Lead) - May 28, 2011
- After cigarettes, government to crack down on chewing tobacco use (Second Lead) - Apr 04, 2011
- WHO warns against tobacco industry pushing sales - May 30, 2012
- Harm reduction ciggies 'more harmful than conventional brands' - Oct 21, 2010
- Harsher cancer warning on tobacco products in the offing - May 25, 2011
- Estrogen may promote spread of precancerous cells in oral cavity - Jan 04, 2011
Tags: carcinogens, chemical research in toxicology, chewing tobacco, dental students, false impression, genetic material, gum disease, harmful health effects, journal chemical research in toxicology, key family, knowledge gap, laboratory rats, mediterranean region, northern africa, oral cancer, prescription drugs, sex hormones, south asian origin, southeast asia, tobacco use