Smog bad for your heart: StudyJuly 22nd, 2010 - 6:47 pm ICT by ANI
Washington, July 22 (ANI): An early test on rats has provided the first direct indication that smog is bad for heart.
A major component of smog might trigger cell death in the heart, researchers said at the American Heart Association’s Basic Cardiovascular Sciences 2010 Scientific Sessions - Technological and Conceptual Advances in Cardiovascular Disease.
The study found that exposure to ground-level ozone over several weeks increased the activity of a substance that triggers cell death in the heart.
Ozone becomes a major component of smog when it forms near the ground through reactions between sunlight, nitrogen oxides and hydrocarbons from fossil fuels and industrial processes.
“Several epidemiological studies have linked air pollution to the development of cardiovascular disease, but air pollution contains hundreds of chemicals and those studies were unable to separate out the effects of individual components,” Rajat Sethi, an assistant professor in the Department of Pharmaceutical Sciences at the Texas A and M Health Science Center Irma Lerma Rangel College of Pharmacy in Kingsville, Texas said.
“Our study looked for direct evidence of the role of ozone alone in cardiac dysfunction by creating a controlled environment,” he added.
The researchers tested four groups of 10 rats living in clear plastic-glass boxes. The first two groups were exposed for eight hours a day to 0.8 parts per million (ppm) of O3 for either 28 or 56 consecutive days. The other two groups were exposed to 28 days or 56 days of clean, filtered air for eight hours per day. After the eight hours of testing, all the rats experienced 16 hours of clean air overnight.
The study found that the hearts of the O3-exposed rats had increased levels of tumor necrosis factor-alpha (TNF a), an indication of inflammation compared to hearts of the control rats. Increased TNF a levels have been linked to a drop in levels of a heart-protective protein called Caveolin-1 (Cav1). Scientists believe Cav1 protects the heart by binding to a chemical called p38MAPK alpha (p38MAPK a), which is known to be a cell death signaling chemical, Sethi said.
The researchers found that Cav1 levels decreased in the hearts of rats exposed to O3 compared to the hearts of control rats who breathed filtered air.
“We believe the decreased levels of Cav1 make more unbound p38MAPK a available for telling the heart cells to die. That link between Cav1 and O3 has never been shown in the heart,” Sethi said. (ANI)
- Ozone exposure could trigger heart attacks - Jun 26, 2012
- Manipulating muscle stem cells could treat muscular dystrophy - Oct 10, 2010
- Chronic inhalation of polluted air 'can lead to inflammation, heart risk' - Apr 17, 2011
- New drug restores responsiveness to morphine - Jan 31, 2011
- Thoughtfulness helps ease tiffs between couples - Nov 14, 2009
- Use 'thoughtful words' while fighting with partner to stay fit - Nov 14, 2009
- Poor response to anti-anemia drug linked to heart disease risk - Dec 29, 2010
- Ozone not healing - Oct 21, 2011
- Excess light at night can contribute to air pollution: Study - Dec 16, 2010
- How stressed cells boost production of key blood clotting factor - Feb 05, 2011
- Indoor plants can reduce toxic ozone levels in offices, homes - Sep 09, 2009
- Immune system can abort stem cell regeneration - Nov 21, 2011
- New discovery may help reduce obesity complications - Feb 04, 2010
- Air pollution increases risk of repeat heart attack - Jun 06, 2012
- Study finds how blood clotting and cancer progression are linked - Feb 05, 2011
Tags: air pollution, american heart association, cardiac dysfunction, cardiovascular sciences, conceptual advances, control rats, epidemiological studies, glass boxes, ground level ozone, health science center, heart researchers, heart study, irma lerma rangel college of pharmacy, kingsville texas, m health, nitrogen oxides, parts per million ppm, protective protein, tumor necrosis factor, tumor necrosis factor alpha