Small molecules ‘could block cell proliferation in cancerous human tumor’April 14th, 2011 - 12:44 pm ICT by ANI
Washington, Apr 14 (ANI): An Indian-origin scientist and his colleagues have identified three novel small molecules that interrupt a crucial cellular communication pathway that regulates many aspects of development and cancer.
These could provide the basis for innovative therapies for colorectal cancer and other diseases associated with aberrations in this pathway.
Ramanuj DasGupta, assistant professor of Pharmacology at New York University School of Medicine and his colleagues identified the molecules as inhibitors of the Wnt signaling pathway. This pathway is of special interest to scientists because it controls many biological processes by promoting cell-to-cell communication.
“Our study demonstrates that the three newly identified compounds are capable of blocking cell proliferation in cancerous human tumor biopsy cells,” said DasGupta.
“These molecules hold a lot of promise towards future Wnt-based drug development for cancer treatments,” he said.
“They may allow the compounds to be used for specific therapeutic purposes in humans to induce the death of Wnt-dependent or Wnt -addicted cancer cells and tumor tissues without affecting the growth and proliferation of normal healthy cells.”
The scientists demonstrated that the molecules suppressed the activity of the Wnt signaling pathway-without disrupting other cellular functions-in human colon cancers from biopsies, in colon cancer cell lines, and in a mouse tumor-xenograft model. In all instances, the inhibitors stopped the proliferation of cancerous cells in the laboratory dish or in the mouse.
In the study, the researchers used an innovative, integrated screening platform combining RNA interference (RNAi) -technology and high-throughput chemical genetic screening to examine the potency of 14,977 compounds on the activity of the Wnt pathway.
This targeted screening methodology helped identify the three promising novel inhibitors capable of blocking Wnt target genes in various mammalian cancer cell lines including human colon and breast cancer cells.
The study is published in the current issue of Proceedings of the National Academy of Sciences. (ANI)
- New path discovered for colon cancer drug discovery - Nov 20, 2010
- Molecule that can increase blood flow in vascular disease identified - Mar 11, 2011
- Compounds offer novel approach to fight cancer - Nov 02, 2010
- New drug shrinks cancer, with few side effects - Apr 07, 2011
- New way to halt expansion of breast cancer stem cells discovered - Nov 24, 2010
- Compound to starve cancers of sugar-based building blocks found - Nov 19, 2010
- Arsenic could be a potential cancer treatment - Jul 13, 2010
- New discovery opens up novel strategy for combating malaria - Mar 09, 2011
- New way found to kill malaria parasite - Mar 09, 2011
- Possible new treatment strategies for pancreatic cancer found - Mar 04, 2011
- Genome code for most common form of pediatric brain cancer cracked - Dec 17, 2010
- Broccoli and brussels sprouts boost sunscreens' cancer fighting abilities - Apr 27, 2011
- What prompts lung cancer to spread - Jul 03, 2009
- Arsenic-based agent shuts down hard-to-treat cancers - Dec 23, 2010
- New discovery may help explain how cancer cells spread - Jun 01, 2010
Tags: cancer cell, cancer cells, cancerous cells, cell proliferation, cellular functions, colon cancer, colon cancers, communication pathway, high throughput, human colon, human tumor, innovative therapies, laboratory dish, new york university, new york university school of medicine, novel inhibitors, rna interference, tumor biopsy, wnt pathway, wnt signaling pathway