Slow growth as a fetus linked to type 2 diabetes in adulthoodMay 9th, 2008 - 1:11 pm ICT by admin
Washington, May 9 (ANI): A new study from University of Pennsylvania, Philadelphia has revealed that slow growth as a fetus can cause type 2 diabetes in adulthood.
The study led by Rebecca Simmons suggested that Intrauterine growth retardation (IUGR), which results in a baby having a low weight at birth may be linked to diabetes in adulthood.
This is because the expression of key genes is altered during fetal development, which affects disease susceptibility.
Prior studies conducted using a rat model of IUGR have shown decreased fetal expression of the gene Pdx1, which is critical for the development and function of the cells that become defective in type 2 diabetes (pancreatic beta-cells), and adult onset of diabetes.
The present study also conducted using rat model of IUGR found that the expression of Pdx1 was reduced in pancreatic beta-cells throughout life following IUGR.
The molecular mechanisms (known as epigenetic mechanisms because they affect gene expression without altering the information in the gene) that reduced Pdx1 expression in pancreatic beta-cells were found to change during development.
One mechanism was observed in the fetus, one following birth, and one after the onset of diabetes in adulthood.
However, the study also suggested that the mechanisms reducing Pdx1 gene expression in the fetus and following birth could be reversed, whereas those reducing Pdx1 gene expression in the adult were irreversible.
These data provide new insight into the mechanisms by which diabetes develops in adulthood following IUGR.
The study appears in Journal of Clinical Investigation. (ANI)
- Scientists discover a new way insulin-producing cells die - Feb 27, 2011
- Mechanism that could provide potential cure for diabetes identified - Apr 30, 2011
- Scientists reveal new clues to origin of diabetes - Oct 13, 2010
- Circadian clock found in pancreas linked to diabetes - Jun 19, 2010
- Mother's poor diet 'can make child diabetic' - Mar 08, 2011
- Study on insulin-creating cell may lead to better diabetes treatment - Oct 29, 2010
- New genes linked to Type 2 diabetes identified - Jun 28, 2010
- Mums' stem cells could be key to treating genetic disease before birth - Jan 19, 2011
- Bacteria linked to preterm births, developmental problems in newborns - Jan 28, 2011
- Early life stress has lasting effects on gene vital to normal brain function - Sep 29, 2010
- Anti-diabetic effects of sodium tungstate unravelled - Aug 28, 2009
- Gene key to kidney disease, failure and death identified - Apr 24, 2011
- Exposure to low doses of BPA alters mice ovaries - Aug 26, 2010
- Why some kids are harmed by mum's drinking, but others aren't - Mar 24, 2011
- Missing sugar molecule 'increases diabetes risk' - Feb 25, 2011
Tags: adult onset, adulthood, beta cells, diabetes, disease susceptibility, epigenetic mechanisms, fetal development, fetus, gene expression, genes, insight, intrauterine growth retardation, iugr, journal of clinical investigation, molecular mechanisms, pennsylvania philadelphia, rat model, rebecca simmons, type 2 diabetes, university of pennsylvania