Sleep apnea occurring during REM sleep linked to type 2 diabetes
June 16th, 2009 - 12:57 pm ICT by ANIWashington, June 16 (ANI): Obstructive sleep apnea (OSA) episodes occurring during rapid eye movement (REM) sleep is significantly associated with type 2 diabetes, according to a new study.
Principle investigator Kamran Mahmood, MD, MPH, of the University of Illinois at Chicago, said that the significant association of REM-related OSA and type 2 diabetes was surprising.
“We believe that REM-related OSA is a marker of early OSA, especially in women and patients younger than 55 years,” said Mahmood.
“Generally, OSA is worse in REM sleep compared to non-REM sleep because of neurologically mediated impairment of skeletal muscles of upper airway and ventilation. This may be the reason for closer association of REM-related OSA and type 2 diabetes,” Mahmood added.
Results indicated that the adjusted odds ratio for type 2 diabetes was 2.0 times higher in patients with REM-related OSA, defined as having an REM apnea-hypopnea index (AHI) of 10 or more breathing pauses per hour of REM sleep.
The prevalence of type 2 diabetes was 30.1 percent in participants with OSA and 18.6 percent in those without OSA; however, the overall association between OSA and diabetes became non-significant after controlling for covariates such as body mass index (BMI), age, race and gender.
Middle-aged participants with OSA had an adjusted odds ratio for type 2 diabetes that was 2.8 times higher than younger or middle-aged people without OSA.
Hispanics and older patients referred for OSA evaluation had a higher prevalence of type 2 diabetes; this relationship was not affected by OSA.
The study gathered data from 1,008 consecutive patients who were evaluated for OSA by comprehensive polysomnography at the University of Illinois at Chicago; 66.9 percent were African American, 16.9 percent were Caucasian, 14.9 percent were Hispanic and 1.3 percent were Asian.
OSA was defined as an AHI of five or more breathing pauses per hour of sleep and was diagnosed in 745 individuals (74 percent); the 263 adults (26 percent) who did not have OSA served as the control. Men comprised 52.8 percent of the OSA group but only 28.5 percent of the control group.
The study was published in the June 15 issue of the Journal of Clinical Sleep Medicine. (ANI)
- Severe sleep apnea reduces nightmare recall frequency - Feb 15, 2010
- Poor sleep aggravates young diabetics' condition - Jan 01, 2012
- People with sleep apnea 'more likely to develop aggressive heart disease' - Dec 01, 2010
- Obstructive sleep apnea may increase heart disease risk: Study - Jul 13, 2010
- Obstructive sleep apnea 'can make diabetes worse' - Jan 15, 2010
- Obstructive sleep apnea quiet common in adults with Down syndrome - Aug 16, 2009
- Sleep apnea treatment staves off heart failure - Mar 14, 2012
- 81pc of hospital patients at high risk for obstructive sleep apnea - Nov 02, 2010
- Obstructive sleep apnea patients at increased heart disease risk - Jan 25, 2010
- Breathing device helps kids with sleep apnea - Feb 13, 2012
- Sleep apnea ups stroke risk - Apr 08, 2010
- Sleep apnea remains widely undiagnosed in obese diabetics - May 22, 2009
- Sleep apnea undiagnosed among obese type-2 diabetics - May 21, 2009
- Long, short sleep durations linked increased diabetes risk - Jun 08, 2009
- Death risk high in older adults with sleep apnea and daytime sleepiness - Apr 02, 2011
Tags: adjusted odds ratio, body mass index, body mass index bmi, caucasian, consecutive patients, hispanics, marker, non rem sleep, obstructive sleep, polysomnography, prevalence, principle investigator, rapid eye movement, skeletal muscles, sleep apnea, type 2 diabetes, university of illinois, university of illinois at chicago, upper airway, ventilation