Scientists one-step closer to developing drugs against winter vomiting disease
June 11th, 2009 - 2:00 pm ICT by ANI ( Leave a comment )Washington, June 11 (ANI): Scientists have made a new discovery that they say has put them one step closer to developing drugs against the winter vomiting disease.
They have found that the virus that causes winter vomiting disease invades cells by attaching to particular sugar molecules on the surface of the cells.
“We are aiming to develop a drug that can be given to vulnerable persons and to children in day-care when it has become clear that another epidemic is starting to break out. More research will, however, be required. Our results are important steps along the way, but it will probably be several years before a drug is commercially available”, said Gustaf Rydell.
Rydell’s study has shown how the virus for winter vomiting disease can attach to cells by binding to special sugar chains.
One of these chains is characterised in that it has a monosaccharide known as sialic acid at its end.
Rydell’s study has also shown that the virus binds to such sugar chains even when they are not part of the cell surface.
This means that it may be possible for the sugar chains to prevent the virus infecting the cells by blocking its binding structures.
“Our results suggest that the sugar chains that have sialic acid are important for infection by the virus, but this must be confirmed. If it is true, it would be possible to develop a drug that blocks the access of the virus to the sugar molecule. One thing that we must investigate first, however, is whether there are other target molecules that the virus can use to enter the cell. These may be the starting point for even more effective drugs”, said Rydell.
Rydell presented his thesis at the Sahlgrenska Academy, University of Gothenburg, Sweden. (ANI)
- Molecular changes that helped Tamiflu resistance explained - Jun 04, 2010
- How cholera bug invades the gut - Jan 29, 2012
- How antiviral drugs block flu virus - Feb 04, 2010
- Non-stick protein coating in semen cuts HIV infection - Sep 24, 2010
- Genetic changes responsible for sweet tooth - Apr 05, 2011
- Non-human sugar in drugs causes chronic inflammation - Jul 26, 2010
- Sugars play key role in bacterial infection in humans: Study - Mar 18, 2011
- Missing sugar molecule 'increases diabetes risk' - Feb 25, 2011
- Molecule engineered to attack HIV shows positive results - Jan 20, 2011
- Is cure for common cold in sight? - Nov 02, 2010
- Cure for the common cold a step closer - Nov 02, 2010
- Chink in the armour of viral ''tummy bug'' identified - Dec 24, 2008
- Cellular protein that acts as receptor for Ebola virus identified - May 03, 2011
- Scientists block multiple sclerosis in mouse model - Mar 08, 2011
- Sweet discovery offers protection against killer viruses - Nov 04, 2010
Tags: cell surface, cells, characterised, day care, epidemic, gothenburg sweden, gustaf, monosaccharide, new discovery, rydell, sahlgrenska, scientists, sugar chains, sugar molecule, sugar molecules, target molecules, thesis, university of gothenburg, vomiting, vulnerable persons