Thaindian News

Washington, Aug 4 (ANI): Epilepsy sufferers have been given fresh hope after scientists at Leeds prevented the condition from being passed on to mice offspring.

The researchers were able to do so after identifying that a faulty version of a gene known as Atp1a3 is responsible for causing epileptic seizures in mice.

The achievement may herald new therapies for people suffering from the condition.

“Atp1a3 makes an enzyme called a sodium-potassium pump that regulates levels of sodium and potassium in the brain’s nerve cells. An imbalance of sodium and potassium levels has long been suspected to lead to epileptic seizures, but our study is the first to show beyond any doubt that a defect in this gene is responsible,” lead author Dr Steve Clapcote, of the University of Leeds’ Faculty of Biological Sciences, as saying.

To prove the gene’s role, the research team studied a special strain of mouse, called Myshkin, which has an inherited form of severe epilepsy.

The researchers found that these mice have a defective Atp1a3 gene, which led to them all having spontaneous seizures displaying the characteristic brain activity of epilepsy.

To confirm that the seizures were epileptic, the team showed that mice treated with an antiepileptic drug, valproic acid, had fewer, less severe seizures.

When the epileptic Myshkin strain was bred with a transgenic mouse strain that has an extra copy of the normal Atp1a3 gene, the additional normal gene counteracted the faulty gene - resulting in offspring, which were completely free from epilepsy.

“Our study has identified a new way in which epilepsy can be caused and prevented in mice, and therefore it may provide clues to potential causes, therapies and preventive measures in human epilepsy,” Dr Clapcote said.

“Our results are very promising, but there’s a long way to go before this research could yield new antiepileptic therapies. However, the human ATP1A3 gene matches the mouse version of the gene by more than 99 per cent, so we’ve already started to screen DNA samples from epilepsy patients to investigate whether ATP1A3 gene defects are involved the human condition,” Dr Clapcote added.

The study has been published in the US journal Proceedings of the National Academy of Sciences (PNAS). (ANI)