Scientists create software to unravel the genetics of inflammation

December 1st, 2007 - 1:40 pm ICT by admin  

Washington, December 1 (ANI): Researchers at Wake Forest University Baptist Medical Center have developed a powerful tool to aid scientists in studying the genetics of inflammatory diseases, using information about the genes that are known to be linked to inflammation.

Dr. Matthew Loza of the Center for Human Genomics at Wake Forest University School of Medicine, has revealed that a web-based software called Ingenuity Pathway Analysis can enable the systematic mapping of pathways (chains of genes) and sub-pathways that contribute to various aspects of inflammation.

We basically organized the inflammation-associated genes in a systematic way. Before, a random list of genes involved in inflammation was all you had. We started with that same list, but then built these networks to bring all these different genes together, said Loza, who is also the lead author of the study.

The research teams work has led to the development of two customized panels for analysing genetic variations in the inflammation pathwaysone for European and the other for African descent populations.

The two panels are analysed with the help of special laboratory equipment and computer systems. Investigators can obtain the custom inflammation panel through Affymetrix Corporation.

This is so significant because inflammation is a very hot topic, and many research groups want to study it, said Dr. Bao-Li Chang, assistant professor of pediatrics at Wake Forest and senior author for the study.

We have provided researchers with the tool to effectively and efficiently accomplish their goals, Chang added.

The Public Library of Science has published the study in its online journal PLoS One. (ANI)

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