Researchers show similarity between opiate and nicotine addiction

February 13th, 2008 - 5:34 pm ICT by admin  

Washington, Feb 13 (ANI): Researchers at the University of Chicago Medical Center have found similarity between opiate and nicotine addiction.

The study indicates that the effects of nicotine and opium on the brain’s reward system are equally strong in key pleasure-sensing areas of the brain the nucleus accumbens.

“Testing rat brain tissue, we found remarkable overlap between the effects of nicotine and opiates on dopamine signaling within the brains reward centres,” said Daniel McGehee, Associate Professor in Anesthesia & Critical Care at the University of Chicago Medical Center.

He and his colleagues are exploring the control of dopamine, a key neurotransmitter in reward and addiction.

Dopamine is released in areas such as the nucleus accumbens by naturally rewarding experiences such as food, sex, some drugs, and the neutral stimuli or cues that become associated with them.

Nicotine and opiates are very different drugs, but the endpoint, with respect to the control of dopamine signaling, is almost identical.

There is a specific part of the nucleus accumbens where opiates have been shown to affect behavior, and when we tested nicotine in that area, the effects on dopamine are almost identical, said McGehee.

The study is important as it demonstrates overlap in the way the two drugs work, complementing previous studies that showed overlapping effects on physiology of the ventral tegmenal area, another key part of the brains reward circuitry.

The researchers hope that this study will help identify new methods for treating addiction and not just for one drug type.

“It also demonstrates the seriousness of tobacco addiction, equating its grip on the individual to that of heroin. It reinforces the fact that these addictions are very physiological in nature and that breaking away from the habit is certainly more than just mind over matter,” McGehee said.

The study is published in the February 13 issue of The Journal of Neuroscience. (ANI)

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