Researchers find more effective way to treat Crohn’s disease

February 22nd, 2008 - 5:00 pm ICT by admin  

London, Feb 22 (ANI): A new international study has opened the door to a safer and more effective treatment option for sufferers of Crohn’s disease - a top-down therapy.

The study, led by Dr. Geert DHaens, of the Imelda GI Clinical Research Centre at the Imelda Hospital in Bonheiden, Belgium, demonstrated that the alternative treatment method was more effective at inducing disease remission than the conventional method.

Our study clearly demonstrated that this alternative treatment method was more effective at inducing disease remission than the conventional method, The Lancet quoted Dr. Brian Feagan, Director of Robarts Clinical Trials at Robarts Research Institute at The University of Western Ontario, as saying.

Not only were patients more likely to get their disease under control, but they were also spared exposure to steroids the extended use of which is linked with metabolic disease and even increased mortality. Its simply a safer, more effective treatment method, he added.

The conventional treatment step-up approach for Crohns disease involves first administering steroids in order to control the patients symptoms (abdominal pain and bloody diarrhea); the next step involves administering immune-suppressing drugs, which prepare the body to receive the third medication an antibody that curbs the inflammatory response at the root of the disease.

The alternative strategy, called top-down therapy, employs early use of immune-suppressing drugs combined with an antibody in order to address the disease from the start. Symptom-treating steroids may never even be needed.

In the two-year study, was conducted at research centres in Belgium, Holland, and Germany and involved 129 subjects with active Crohns disease.

64 patients received the conventional step-up treatment and 65 the combined immune-suppressing method (top-down). 60 percent of the top-down subjects were symptom-free by the 26th week of the study, compared to only 36 percent of the step-up subjects.

This study is a milestone in the management of Crohns disease, said DHaens.

It does not look at the effects of single drug intervention but at strategies to alter the natural history of this chronic destructive condition. All classic paradigms for the management of Crohns disease need to be questioned, he added.

Weve seen similar results in top-down, step-up studies of rheumatoid arthritis suggesting that the top-down approach could be the best treatment method for other chronic auto-immune diseases such as ulcerative colitis, said Feagan.

The study is published in the journal The Lancet. (ANI)

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