Probiotic bacteria ‘could help in Crohn’s disease therapy’April 1st, 2011 - 1:15 pm ICT by ANI
Washington, April 1 (ANI): Researchers have suggested that infection with a probiotic strain of E. coli bacteria could help treat and reduce the negative effects of another E. coli infection that may be associated with Crohn’s disease.
Crohn’s disease is a common chronic disorder that affects the gastrointestinal tract and is believed to develop as a result of an aberrant immune response to intestinal microbes in a genetically susceptible host.
Since Crohn’s disease is a clinical subtype of inflammatory bowel disease (IBD) and others have reported successful treatment of IBC with the probiotic E. coli Nissle 1917 (EcN), researchers from the University of Auckland, New Zealand investigated the impact EcN might have on an already established infection with AIEC in cell cultures mimicking those found in the lining of the intestines.
They found that treatment with EcN not only helped prevent the AIEC reference strain LF82 from invading the cells and establishing infection, it also appears to modulate production of immune proteins that cause inflammation.
“This study is the first to our knowledge to show that EcN can reduce some of the negative effects associated with the strain LF82 in an already established AIEC infection and emphasizes the potential of EcN in IBD treatment. In particular the use of this probiotic could be of interest in CD patients harboring pathogenic AIEC,” said the researchers.
The study has been published in the April 2011 issue of the journal Applied and Environmental Microbiology. (ANI)
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Tags: aiec, applied and environmental microbiology, auckland new zealand, cause inflammation, cell cultures, chronic disorder, crohn s disease, e coli, e coli bacteria, e coli infection, ecn, gastrointestinal tract, ibd, immune proteins, immune response, inflammatory bowel disease, probiotic bacteria, susceptible host, university of auckland, university of auckland new zealand