Pregnant mums smoking may decrease daughters fertilityNovember 22nd, 2007 - 12:19 pm ICT by admin
Washington, Nov 22 (ANI): Pregnant women have been given yet another reason to kick the butt with researchers finding that it might decrease their daughters fertility.
The study, by researchers at University of Toronto, Canada, was conducted on a mouse model.
As a part of the research, the boffins injected female mice with polycyclic aromatic hydrocarbons (PAHs) environmental toxins found in cigarette smoke - under the skin.
They found that though pre-pregnancy or lactating mice had normal size litters, their female offspring had markedly reduced numbers of resting and early growing follicles cell clusters that each contain a single egg.
Further studies by the team led by Andrea Jurisicova found that the effects of PAHs on the number of follicles in female offspring were mediated through the aryl hydrocarbon receptor (Ahr), which upregulated expression of the gene Harakiri that makes a protein that causes cells to die by a process known as apoptosis.
The researchers say that the study is important in the human context as well for they found that PAHs triggered similar molecular pathways in human ovarian tissue transplanted into immunocompromised mice.
The study appears in the Journal of Clinical Investigation. (ANI)
Tags: aryl hydrocarbon receptor, cell clusters, cigarette smoke, environmental toxins, female mice, female offspring, fertility, follicles, further studies, harakiri, human context, immunocompromised, journal of clinical investigation, molecular pathways, ovarian tissue, pahs, polycyclic aromatic hydrocarbons, pre pregnancy, university of toronto canada