Plastics chemical BPA linked to PCOSJune 22nd, 2010 - 1:23 pm ICT by ANI
Washington, June 22 (ANI): A new research has found that women with the polycystic ovary syndrome (PCOS), the most common hormone imbalance in women of reproductive age, have higher BPA blood levels.
BPA, or bisphenol A, is a chemical inside some plastics and most canned foods we eat.
In the study, researchers also found that BPA, a known hormone disrupter, is elevated and associated with higher levels of male hormones in the blood of women with PCOS compared with healthy women.
These findings held true for both lean and obese women with PCOS, said Evanthia Diamanti-Kandarakis, study co-author and professor at the University of Athens Medical School in Greece.
“Women with the polycystic ovary syndrome should be alert regarding this environmental contaminant’s potential adverse effects on reproductive aspects of their health problem,” she said.
Excessive secretion of androgens-masculinization-promoting hormones-occurs in PCOS. The syndrome raises the risk of infertility, obesity, Type 2 diabetes and heart disease.
Past studies show that BPA is elevated in women who have had recurrent miscarriages. This chemical can leach into the bloodstream from food and beverage containers that are made of polycarbonate hard plastic or lined with epoxy resins, or from some dental sealants and composites.
In the new study, the researchers divided 71 women with PCOS and 100 healthy female control subjects into subgroups matched by age and body composition (obese or lean).
Blood levels of BPA, compared with those of controls, were nearly 60 percent higher in lean women with PCOS and more than 30 percent higher in obese women with the syndrome.
Additionally, as the BPA blood level increased, so did the concentrations of the male sex hormone testosterone and androstenedione, a steroid hormone that converts to testosterone, Diamanti-Kandarakis reported.
Although BPA is a weak estrogen, excessive secretion of androgens, as seen in PCOS, interfere with BPA detoxification by the liver, leading to accumulation of blood levels of BPA, Diamanti-Kandarakis explained.
“BPA also affects androgen metabolism, creating a vicious circle between androgens and BPA,” she said.
Diamanti-Kandarakis said women with PCOS may want to limit their exposure to BPA.
“However, no one has proved that by reducing BPA levels in PCOS, it will have beneficial effects,” she said.
The results were presented Sunday at The Endocrine Society’s 92nd Annual Meeting in San Diego. (ANI)
- Acupuncture and exercise benefit women with PCOS - Feb 08, 2011
- Brain-hormone circuit that helps police diabetes, female fertility unraveled - Apr 09, 2010
- A missing link from obesity to infertility discovered - Sep 12, 2010
- Even minor weight loss 'ups fertility' in obese women - Jul 01, 2009
- Weight loss improves testosterone levels - Jun 05, 2011
- Diabetes drug may provide protection against endometrial cancer - Apr 06, 2011
- Junk food lowering Delhi girls' puberty age: Doctors - Nov 01, 2011
- Exposure to chemical fosters anxiety - Sep 09, 2012
- Acupuncture, exercise may help women with polycystic ovary syndrome - Aug 21, 2009
- Cash receipts, currency notes carry toxic hazards: Study - Jul 12, 2012
- Chemical found in plastics 'can increase testosterone levels in men' - Aug 26, 2010
- Low testosterone raises risk of diabetes - May 04, 2012
- Acupuncture, exercise may benefit women with PCOS - Jun 30, 2009
- Higher testosterone helps older men preserve muscle mass - Oct 29, 2011
- Male sex hormones in ovaries help regulate female fertility - May 27, 2010
Tags: athens medical school, beverage containers, body composition, dental sealants, diabetes and heart disease, disrupter, environmental contaminant, epoxy resins, excessive secretion, hormone imbalance in women, hormone testosterone, lean women, male hormones, male sex hormone, masculinization, obese women, polycystic ovary syndrome, recurrent miscarriages, reproductive aspects, university of athens