Omega-3 fatty acid kills cancer cells in miceApril 2nd, 2009 - 11:53 am ICT by ANI
Washington, April 2 (ANI): An omega-3 fatty acid found in fish oils has shown some promise to reduce the size of tumours and enhance the positive effects of the chemotherapy drug cisplatin, while limiting its harmful side effects.
A. M. El-Mowafy, a professor at Mansoura University in Egypt, studied the effects of the fatty acid Docosahexanoic acid (DHA) on solid tumours growing in mice.
The researcher also studied how this fatty acid interacts with the drug cisplatin, which is known to cause kidney damage.
El-Mowafy said: “DHA elicited prominent chemopreventive effects on its own, and appreciably augmented those of cisplatin as well. Furthermore, this study is the first to reveal that DHA can obliterate lethal cisplatin-induced nephrotoxicity and renal tissue injury.”
Cold-water fish oil and some vegetable oils are known to be rich in DHA.
This fatty acid is a major component of brain grey matter and of the retina in most mammalian species.
It is considered to be essential for normal neurological and cellular developments.
The authors said: “While DHA has been tentatively linked with protection against cardiovascular, neurological and neoplastic diseases, there exists a paucity of research information, in particular regarding its interactions with existing chemotherapy drugs”.
During the study, the researchers found that DHA acts by reducing white blood cell accumulation, systemic inflammation, and oxidative stress at the molecular level.
The finding attains significance as all these processes have been linked with tumour growth.
El-Mowafy and his colleagues have called for greater deployment of omega-3 in the fight against cancer.
They write: “Our results suggest a new, fruitful drug regimen in the management of solid tumours based on combining cisplatin, and possibly other chemotherapeutics, with DHA.”
The study has been published in the open access journal Cell Division. (ANI)
- Omega-3 fatty acids could help prevent traumatic brain injury - Jan 09, 2011
- Low levels of Omega fatty acids weaken memory - Feb 28, 2012
- Fish diet in pregnancy bolsters progeny's intelligence - Feb 01, 2012
- Eating fish powers brain - Oct 25, 2011
- How omega-3 fatty acids keep blindness at bay - Feb 10, 2011
- Omega-3 fatty acids limit smoking damage - Apr 22, 2012
- Unique genetic adaptation helped our brain grow - Apr 13, 2012
- Fish oil given within 5 hrs after stroke limits brain damage - Nov 09, 2010
- Omega-3 fatty acids good for heart, bad for prostate - Apr 26, 2011
- Fish livers contain beneficial fatty acids - Apr 30, 2011
- Fish-oil components can treat chronic illness? - Oct 09, 2010
- Diets high in fish oil 'help maintain weight during chemotherapy' - Feb 28, 2011
- No old wives' tale: Omega-3 prevents osteoarthritis - Oct 18, 2011
- Omega-3 fatty acid boosts brainpower - Jun 29, 2012
- Bingeing on soda, sweets makes you a dim wit - May 16, 2012
Tags: cancer cells, chemotherapeutics, chemotherapy drug cisplatin, chemotherapy drugs, cisplatin, cold water fish, cold water fish oil, dha, drug regimen, fish oils, grey matter, kidney damage, mammalian species, neoplastic diseases, nephrotoxicity, omega 3 fatty acid, renal tissue, systemic inflammation, tissue injury, white blood cell