Novel human-in-mouse cancer model may lead to improved drugsApril 7th, 2009 - 2:43 pm ICT by ANI
Washington, Apr 7 (ANI): Scientists have successfully created a human-in-mouse cancer model mimicking human tumour behaviours and response - a finding that would pave way for improved cancer drugs.
Researchers at AVEO Pharmaceuticals, Inc., a biopharmaceutical company have engineered normal human breast tissue to express oncogenes, which when introduced in mice, formed human breast tissue in mouse mammary microenvironment.
The tumours, which then develop spontaneously, acquire common and distinct mutations during tumour progression.
This process results in tumours in mice that reflect their human counterparts - exhibiting natural genetic variation akin to that seen in patients.
“Historically, the xenograft models created to analyze how human cancers behave have not been accurate predictors of human responses to various therapeutic agents,” said Dr Robert A. Weinberg, member, Whitehead Institute and professor of biology, MIT.
The HIM tumours also displayed characteristic responses to a targeted therapy known to be effective in humans, specifically Herceptin.
“This represents a big step forward in developing xenograft models that will accurately predict patient responses to agents that are in preclinical development,” he said.
“The HIM model is an exciting, experimentally tractable human in vivo system that holds great potential for advancing our basic understanding of cancer biology and for the discovery and testing of targeted therapies,” he added.
The findings are published in Proceedings of the National Academy of Sciences. (ANI)
- Combo therapy may overcome Herceptin-resistant breast cancer - Mar 14, 2011
- New 'nanodrug' can attack breast cancer cells from the inside out - Mar 30, 2011
- Caffeine-exercise combo protects against skin cancer - Apr 04, 2012
- New way to screen breast cancer cells' ability to metastasize - Jan 09, 2011
- Small molecules 'could block cell proliferation in cancerous human tumor' - Apr 14, 2011
- Key enzyme that controls growth of breast cancer cells identified - Nov 19, 2010
- Super vaccine could knock out 70 percent of cancers - Dec 13, 2011
- Scientists provide genetic evidence that antioxidants can help treat cancer - Feb 16, 2011
- Normal healthy breast cells can help kill cancer cells - Apr 14, 2011
- Silencing 'hedgehog' molecule halts cancer - Jun 06, 2011
- Erectile dysfunction drug could enhance delivery of herceptin to brain tumours - May 08, 2010
- Walnuts reduce breast cancer risk - Sep 02, 2011
- New way to halt expansion of breast cancer stem cells discovered - Nov 24, 2010
- Silica cages help anti-cancer antibodies prevent tumour growth in mice - May 22, 2010
- How HRT and the Pill can lead to breast cancer - Sep 30, 2010
Tags: breast tissue, cancer biology, cancer drugs, distinct mutations, genetic variation, human breast, human cancers, human counterparts, human responses, national academy of sciences, novel human, patient responses, pharmaceuticals inc, preclinical development, proceedings of the national academy, proceedings of the national academy of sciences, robert a weinberg, therapeutic agents, vivo system, whitehead institute