Novel approach may provide new class of diabetes drugs

February 23rd, 2009 - 2:47 pm ICT by ANI  

London, February 23 (ANI): In what may spark a completely new class of drugs to treat type 2 diabetes, University of Oxford researchers have developed a cheap and efficient drug discovery method that can be helpful in identifying a new player in the body’’s insulin secretion process.
The researchers say that the new approach may allow small academic labs to search a large database of drugs to find treatments for diabetes and many other diseases.
They have revealed that they used the new method to identify a small molecule which they are using to understand how insulin is secreted in response to increases in blood sugar.
“A lot of diseases are caused by problems with important proteins within cells. We need to find small molecules that change the function of these proteins both to discover how they work and in addition because these small molecules may also work as treatments for disease. The approach we have developed allows us to do this much more quickly and cheaply than many of the current methods. Ultimately this will speed up the process of getting better treatments into the clinic for patients,” Nature magazine quoted lead researcher Dr Grant Churchill as saying.
Common drugs such as beta-blockers and anti-histamines were discovered with the aid of a proven technique in which a natural chemicals chemical structure is systematically modified.
However, such discoveries involved lengthy chemical syntheses starting with the natural chemical (adrenalin and histamine respectively).
“Our method also begins with the natural chemical but rather than modifying it with a time-consuming and expensive chemical syntheses conducted by a team of chemists, ours uses computers to identify corresponding small molecules for research and medicine. The major difference is that we have linked the computational methods commonly used by pharmaceutical companies to a freely available database of 5 million existing compounds the ZINC database. This means we cut out a hugely time consuming and financially intensive part of the process, which is difficult for small academic labs to do,” Churchill said.
The researchers say that they have successfully tested their approach by successfully identifying a small molecule called Ned-19, which was found after information about the natural chemical NAADP was entered into the computer system and cross referenced with the ZINC database.
Working in collaboration with experts from the University of Southampton, the researchers prepared Ned-19 on a larger scale, and separated it.
The research team conducted some experiments to confirm the activity of Ned-19.
With the aid of Ned-19 in their experiments, the researchers have discovered that NAADP plays a crucial role in insulin secretion, and thus represents a brand new target for diabetes drugs.
Churchill said: “Unfortunately, asking someone to take Ned-19 would actually give them diabetes! But now that we know how important NAADP is we can start to look for drugs that work with NAADP to increase insulin secretion rather than decrease it. In fact, we have colleagues who are already working on this using our tool.”
Professor Douglas Kell, BBSRC Chief Executive said: “This is great news for our community of researchers and will provide a powerful tool for research in the future. This discovery about insulin secretion shows how important it is to have centrally held data repositories that are free to access. Such sharing of data and information can have really significant impact, right across the board.”
A research article on this study has been published in the journal Nature Chemical Biology. (ANI)

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