New way found to suppress ‘hunger hormone’September 16th, 2008 - 3:58 pm ICT by IANS
Washington, Sep 16 (IANS) An Indian American medical scientist has successfully suppressed levels of ‘hunger hormone’ ghrelin in pigs, which could pave the way for a lasting solution to obesity in people.He relied on a minimally invasive mode of vapourising the main vessel carrying blood to the top section or fundus of the stomach. An estimated 90 percent of the body’s ghrelin originates in the fundus, which, without good blood supply, can’t synthesise the hormone.
“With gastric artery chemical embolisation, called GACE, there’s no major surgery,” said Aravind Arepally, clinical director of the Centre for Bio-engineering Innovation, design and associate professor of radiology and surgery at the Johns Hopkins University School of Medicine.
“In our study in pigs, this procedure produced an effect similar to bariatric surgery by suppressing ghrelin levels and subsequently lowering appetite.”
Arepally and his team pointed out that for more than a decade, efforts to safely and easily suppress ghrelin have met with very limited success.
Bariatric surgery - involving the removal, reconstruction or bypass of part of the stomach or bowel - is effective in suppressing appetite and leading to significant weight loss, but carries substantial surgical risks and complications.
“Obesity is the biggest bio-medical problem in the country, and a minimally invasive alternative would make an enormous difference in choices and outcomes for obese people,” Arepally said.
Arepally and colleagues conducted their study over four weeks, using 10 healthy, growing pigs; after an overnight fast, the animals were weighed and blood samples were taken to measure baseline ghrelin levels. Pigs were the best option, because of their human-like anatomy and physiology, he said.
Using X-ray for guidance, researchers threaded a thin tube up through a large blood vessel near the pigs’ groins and then into the gastric arteries supplying blood to the stomachs.
There, they administered one-time saline injections in the left gastric arteries of five control pigs, and in the other five, one-time shots of sodium morrhuate, a chemical that destroys the blood vessels.
The team then sampled the pigs’ blood for one month to monitor ghrelin values. The levels of the hormone in GACE-treated pigs were suppressed up to 60 percent from baseline.
These findings were reported in the Tuesday online edition of Radiology.
- Scientist suppress hunger hormone - Sep 16, 2008
- Indian doctors give 250 kg Tanzanian new lease of life - May 06, 2011
- Bariatric surgery bringing hope for diabetics (Nov 14 is World Diabetes Day) - Nov 13, 2011
- Device that 'makes you feel full' may end your weight woes - Oct 16, 2010
- Weight loss improves testosterone levels - Jun 05, 2011
- Bariatric surgery is better at controlling glucose levels than dieting - Apr 28, 2011
- Test providing new pathway for identifying obesity, diabetes drugs developed - Sep 17, 2010
- Gastric bypass surgery 'can help lower cholesterol' - Jun 26, 2010
- Fight obesity to fight ailments, say doctors (Nov 26 is Anti-Obesity Day) - Nov 26, 2010
- Kashmiri youth survives tumor size of a cricket ball - Apr 27, 2012
- Bariatric surgery can 'safely' cut health risk in severely obese - Mar 15, 2011
- Why we reach for chocolates during stress? - Jun 24, 2011
- Trial underway to test whether surgery is best option for type 2 diabetes - Feb 11, 2011
- Maternal obesity may lead to infertility in the next generation - Mar 24, 2011
- Pleasure eating may fuel obesity - May 03, 2012
Tags: anatomy and physiology, bio engineering, blood samples, blood supply, blood vessel, clinical director, engineering innovation, enormous difference, fundus of the stomach, ghrelin, good blood, innovation design, johns hopkins university, johns hopkins university school, johns hopkins university school of medicine, major surgery, medical scientist, school of medicine, thin tube, x ray