New technique points out cellular-level changes within deep brain regions
January 19th, 2011 - 6:32 pm ICT by ANILondon, Jan 19 (ANI): Scientists say that a groundbreaking technique can help explore changes taking place within the deep regions of the brain at the cellular level.
The findings could lead to greater information on how the brain adapts to changing situations, including repeated drug exposure.
Researchers at Stanford University used time-lapse fluorescence microendoscopy, a technique that uses miniature probes to directly visualize specific cells over a period of time, to explore structural changes that occur in neurons as a result of tumor formation and increased stimulation in the mouse brain.
“Continued drug use leads to changes in neuronal circuits that are evident well after a person stops taking an addictive substance,” said Nora D. Volkow, director of the National Institute on Drug Abuse (NIDA), US.
“This study demonstrates an innovative technique that allows for a glimpse of these cellular changes within the brain regions implicated in drug reward, providing an important tool in our understanding and treatment of addiction,” she added.
The researchers focused on two brain regions for the study - the hippocampus and striatum.
The striatum, a brain region important for motor function and habit formation, is also a major target for abused drugs.
Some researchers believe that a shift in activity within the striatum is at least partly responsible for the progression from voluntary drug-taking to addiction.
The new technique could allow a better understanding of how these processes occur at the cellular level, leading to insights into mechanisms underlying addictive behaviours.
“The results should now allow neuroscientists to track longitudinally in the living brain the effects of drugs of abuse at the levels of neural circuitry, the individual neuron, and neuronal dendrites,” said another researcher Mark Schnitzer.
The study has been published in Nature Medicine. (ANI)
- A closer look into how addiction hijacks the brain - Feb 24, 2011
- Tiny RNA molecule could prevent cocaine addiction - Jul 09, 2010
- How HIV affects brain function in its initial stages - Mar 03, 2011
- How second-hand smoke may increase vulnerability to nicotine addiction - May 03, 2011
- Rare protein may regulate cocaine intake - Aug 16, 2010
- Cocaine abusers can control cravings - Dec 01, 2009
- Certain genetic makeup reduces the brain's neurons in drug addicts - Mar 08, 2011
- Technique to visualize 'your brain on drugs' developed - Apr 27, 2010
- Why cocaine is so addictive - Oct 19, 2010
- Why teens are more vulnerable to drug addiction, behavioral disorders - Jan 27, 2011
- Toxin that plays key role in triggering Parkinson's disease identified - Feb 11, 2011
- New study sheds light on the brain's ability to reorganize itself - Mar 19, 2011
- Cell phone use does affect brain but health consequences unknown - Feb 23, 2011
- Novel molecular pathway underlying Parkinson's disease identified - Sep 14, 2010
- Brain can compensate loss of new cells - Mar 20, 2011
Tags: abused drugs, addictive substance, brain region, brain regions, cellular changes, drug reward, drugs of abuse, effects of drugs, habit formation, london jan, miniature probes, mouse brain, national institute on drug abuse, neural circuitry, neuronal circuits, neuronal dendrites, regions of the brain, stanford university, tumor formation, volkow