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Washington, Feb 18 (ANI): A University of Pennsylvania research is trying to crack the code of which strain of flu will be prevalent in a given year, with major implications for global public health preparedness.

Joshua Plotkin and Sergey Kryazhimskiy of the University of Pennsylvania, conducted the research with colleagues at McMaster University and the Institute for Information Transmission Problems of the Russian Academy of Sciences.

Plotkin believes that his group’s computational study of 40 years of flu genomes offers a new way of looking at mutations: by cataloging pairs of genetic changes that have occurred in rapid succession, observing that a mutation in one half of the pair can act as an early warning sign of a mutation about to occur in the other.

Tracking single mutations in a vacuum is not always enough to understand how the flu virus evolves.

“Sometimes a mutation is functional or adaptive only if it’s in the context of a certain genetic background - that is, if the protein already has some other mutation,” said Plotkin.

The influence such combinations have on an organization’s adaptive fitness is known as epistasis.

“If you see a mutation occur in Site A and then very soon after you see a mutation in Site B, and this pattern happens repeatedly, then you have some evidence that A and B influence fitness epistatically.

“The first mutation might be useless on its own, but it might be a prerequisite for the second mutation to be useful. The first mutation is like giving you a nail, and the second one is like giving you a hammer,” he said.

Because the studied mutations generally affect the surface proteins that determine whether the virus can enter and infect human cells, being able to predict what mutations are likely to happen in the near future has lifesaving applications.

The findings have been published in the journal PLoS Genetics. (ANI)