New hybrid drug, derived from turmeric, may benefit stroke victimsFebruary 10th, 2011 - 3:15 pm ICT by ANI
Washington, Feb 10 (ANI): Researchers at Cedars-Sinai Medical Center have created a new molecule from curcumin, a chemical component of the golden-colored spice turmeric, and found that it affects mechanisms that protect and help regenerate brain cells after stroke.
The new curcumin-hybrid compound-CNB-001-does not attack clots but instead repairs stroke damage at the molecular level that feed and support the all-important brain cells, neurons.
“CNB-001 has many of the same benefits of curcumin but appears to be a better choice of compound for acute stroke because it crosses the blood-brain barrier, is quickly distributed in the brain, and moderates several critical mechanisms involved in neuronal survival,” said research scientist Paul A. Lapchak, director of Translational Research in the Department of Neurology at Cedars-Sinai Medical Center, adding that he and his colleagues expect the new drug to move to human clinical trials soon.
CNB-001protects brain cells from damage by repairing four major pathways. One mechanism also plays a major role in the growth and survival of neurons.
The drug reduced stroke-caused “motor deficits”-problems of muscle and movement control-in this laboratory study. It was effective when administered up to an hour after stroke, which correlates with about three hours in humans, the same time frame for which tPA is currently approved.
The findings were presented at the American Heart Association International Stroke Conference in Los Angeles. (ANI)
- Drug from Indian spice builds brain cells after stroke - Feb 10, 2011
- Compound derived from turmeric has neuroprotective effects - Dec 16, 2010
- Immunity boosting vitamin can fight superbugs - Aug 28, 2012
- Erectile dysfunction drug could enhance delivery of herceptin to brain tumours - May 08, 2010
- Prevention of mental decline in aging rats offers hope to patients with Alzheimer's - Jul 09, 2010
- Turmeric-based drug being tested against Alzheimer's - Feb 15, 2012
- Soon, a 'nano drug' jab that hits brain tumour's bullseye - Nov 06, 2010
- Human umbilical cord blood cells boost survival, maturation of key brain cells - Dec 15, 2010
- Brain may use clot-busting drug naturally to offer protection against stroke - May 06, 2010
- Human placenta stem cells show therapeutic potential in stroke models - Feb 02, 2011
- New drug limits brain damage in stroke - Jul 27, 2012
- Newly identified compound to pave way for brain-protecting drugs - Jan 26, 2010
- New therapy could restore mobility in stroke victims - Nov 08, 2010
- Study identifies immune system 'trigger' that fights disease - Apr 30, 2011
- 'Smart' adult stem cells repair heart in 'landmark work' - Aug 17, 2010
Tags: acute stroke, american heart association, blood brain barrier, brain cells, cedars sinai medical, cedars sinai medical center, chemical component, department of neurology, human clinical trials, international stroke conference, laboratory study, molecule, motor deficits, neuronal survival, pathways, research scientist, sinai medical center, stroke damage, stroke victims, tpa