New discovery shows promise against Parkinson’s, Alzheimer’sDecember 8th, 2010 - 5:02 pm ICT by ANI
Washington, Dec 8 (ANI): Scientists have discovered a family of small molecules that holds promise in protecting brain cells against nerve-degenerative diseases such as Parkinson’s, Alzheimer’s and Huntington’s.
Researchers at the Southern Methodist University (SMU) and The University of Texas at Dallas, who made the discovery, are still conducting trials on humans.
EncephRx, a biotechnology and therapeutics company, will develop drug therapies based on the new class of compounds as a pharmaceutical for preventing nerve-cell damage, delaying onset of degenerative nerve disease and improving symptoms.
If proved effective and nontoxic in humans, EncephRx’s small-molecule pharmaceuticals would be the first therapeutic tools able to stop affected brain cells from dying.
“Our compounds protect against neurodegeneration in mice. Given successful development of the compounds into drug therapies, they would serve as an effective treatment for patients with degenerative brain diseases,” said Edward R. Biehl of the SMU.
“Additional research needs to be done, but these compounds have the potential for stopping or slowing the relentless loss of brain cells in diseases such as Alzheimer’s and Parkinson’s,” said Santosh R. D’Melloof the UT Dallas.
The most promising lead compound, designated HSB-13, was tested in Huntington’s disease animal models. It not only reduced degeneration in a part of the forebrain but also improved behavioural performance while proving nontoxic.
The compound also was efficacious in a commonly used fly model of Alzheimer’s disease.
The findings were published in the Journal of Neuroscience Research. (ANI)
- This substance tricks brain to ease Parkinson's - Apr 21, 2011
- A breakthrough in Alzhemier's or Parkinson's treatment? - May 07, 2012
- How misfolded protein spreads from cell to cell, potentially spreading disease - Feb 19, 2011
- New compounds may help develop drugs for degenerative nerve diseases - Jan 20, 2010
- Molecular pathway responsible for Parkinson's disease identified - Jul 29, 2010
- New clues about cause of brain cell death in Parkinson's, Alzheimer's - Jul 30, 2010
- Scientists produce compound that may treat Parkinson's disease - Feb 12, 2011
- Excess copper, iron linked with Alzheimer's - May 22, 2011
- Chemicals in apple skins, red wine, tumeric could help fight Alzheimer's - Nov 30, 2010
- Scientists identify proteins that can check 130 illnesses - Dec 20, 2010
- 3D microscopy to help crack Alzheimer's secrets - Feb 19, 2012
- Second molecule in Alzheimer's toxic duo identified - Feb 04, 2011
- Scientist converts skin cells into brain cells - Jul 29, 2011
- Nano tool inspired by silk moth antenna could aid Alzheimer's research - Mar 01, 2011
- New method to cleanse brain of Alzheimer's plaques developed - Dec 10, 2010
Tags: additional research, animal models, biehl, brain cells, degenerative brain diseases, degenerative diseases, degenerative nerve disease, drug therapies, fly model, forebrain, journal of neuroscience research, lead compound, nerve cell damage, neurodegeneration, new discovery, relentless loss, santosh, southern methodist university, therapeutic tools, university of texas at dallas