Nanobubbles ‘can detect and eliminate prostate cancer cells’September 28th, 2010 - 11:49 am ICT by ANI
Washington, Sept 28 (ANI): Scientists at Rice University were able to use plasmonic nanobubbles in living organisms to detect and eliminate implanted human prostate cancer cells.
Dmitri Lapotko showed that the nanobubbles, generated around gold nanoparticles with a laser pulse, could detect and destroy cancer cells in vivo by creating tiny, shiny vapour bubbles that reveal the cells and selectively explode them.
Their animal model, the zebra fish, is nearly transparent, which makes it ideal for such in vivo research. The study has important implications in theranostics of cancer and other diseases at the cellular level.
First a short laser pulse overheated the surface of the nanoparticles and evaporated a very thin volume of the surrounding medium to create small vapour bubbles that expanded and collapsed within nanoseconds; this left cells undamaged but generated a strong optical scattering signal that was bright enough to detect a single cancer cell.
A second, stronger pulse generated larger nanobubbles that exploded the target cell without damaging surrounding tissue in the zebra fish. Scattering of the laser light by the second “killer” bubble confirmed the cellular destruction.
The nanobubbles avoid the pitfalls of chemo or radiative therapy that can damage healthy tissue as well as tumours.
“It’s not a particle that kills the cancer cell, but a transient and short event. We’re converting light energy into mechanical energy,” Lapotko said.
“Being a stealth, on-demand probe with tunable function, the plasmonic nanobubble can be applied to all areas of medicine, since the nanobubble mechanism is universal and can be employed for detecting and manipulating specific molecules, or for precise microsurgery.”
The study is published in the October print edition of the journal Biomaterials. (ANI)
- Nanobubbles may help destroy cancer cells - Feb 05, 2010
- Soon, collapsing bubbles to kill cancer cells - Aug 21, 2010
- Raman effect makes cancer detection possible - Apr 21, 2011
- New way to screen breast cancer cells' ability to metastasize - Jan 09, 2011
- Scientists introduce thermotherapy as a chemotherapy alternative - Nov 23, 2010
- Scientists creating 'golden bullet' for cancer - Mar 13, 2010
- New therapy shows promise against brain cancer - Feb 02, 2011
- New way to treat cancer using gas bubbles - Jun 28, 2010
- Ultra-sensitive sensor to help detect cancer signs, hidden explosives - Mar 22, 2011
- Scientists use gold nanospheres, near-infrared light to cook tumour - Feb 02, 2009
- Soon, localized delivery of anti-cancer drug by remote-controlled microcarriers - Mar 16, 2011
- Soon, vaccinations at the speed of light - courtesy lasers - Jul 30, 2010
- Promising new cancer treatment 'fries' cells inside tumors - Nov 24, 2010
- Detecting zinc could pave way for better diabetes treatment - Jul 04, 2011
- Shaped pulses could make opaque film see-through - Feb 27, 2011
Tags: animal model, biomaterials, cancer cell, cellular destruction, cellular level, gold nanoparticles, human prostate cancer, laser light, laser pulse, light energy, living organisms, mechanical energy, microsurgery, prostate cancer, prostate cancer cells, radiative, rice university, target cell, thin volume, zebra fish