Mechanism that regulates movement of blood-forming stem cells in body identifiedMarch 26th, 2009 - 5:14 pm ICT by ANI
London, Mar 26 (ANI): Keck School of Medicine of the University of Southern California (USC) researchers have identified a mechanism that helps regulate the movement of blood-forming stem cells in the body.
The finding could lead to improvements in the efficiency of bone marrow transplants.
“By identifying the key mechanism by which these stem cells home and engraft to the bone marrow, it may be possible to pharmacologically treat the cells to activate this pathway and thus increase the effectiveness of bone marrow transplants,” Nature magazine quoted lead author Gregor Adams, Ph.D., assistant professor of cell and neurobiology at the Keck School as saying.
In the study conducted using mouse model, the researchers found that blood-forming stem cells that lacked a specific signalling molecule, called GalphaS, did not home to or engraft in the bone marrow.
“Here we show that the GalphaS pathway is a critical intracellular pathway involved in this process,” he said.
“Currently, large numbers of blood-forming stem cells are required in bone marrow transplantation due to the limited efficiency of the homing process.
This study opens up the possibility of treating bone marrow cells with GalphaS pathway activators as a means to increase the effectiveness of bone marrow transplants,” he added. (ANI)
- Long-term pesticide exposure is harmful: STM study - Jun 20, 2012
- Mums' stem cells could be key to treating genetic disease before birth - Jan 19, 2011
- New 'stretchy' technique generates 3 times more stem cells than usual - Oct 04, 2010
- Menstrual blood stem cells can treat many ailments - May 04, 2011
- Iraqi woman gets new life with bone marrow transplant in India - Sep 23, 2010
- Sahara Hospital to start bone-marrow transplant - Sep 24, 2011
- New hope for patients with end-stage liver disease - Jan 12, 2011
- How bone-marrow stem cells survive in low-oxygen environments - Sep 04, 2010
- Lasers to treat human heart after attack - Aug 12, 2011
- Stem cells may help treat aggressive multiple sclerosis - Mar 22, 2011
- Technique to treat the donor larynx developed - May 01, 2011
- New study paves for novel treatments for regenerating liver, bone marrow - Nov 13, 2010
- 'Mini' transplant may safely reverse severe sickle cell disease in adults - Dec 10, 2009
- Exercise fights obesity by turning stem cells into bone - Sep 02, 2011
- Scientist create white blood cells directly from embryonic and adult stem cells - Aug 11, 2009
Tags: activators, assistant professor, bone marrow cells, bone marrow transplantation, bone marrow transplants, efficiency, improvements, intracellular, keck school of medicine, large numbers, molecule, mouse model, nature magazine, neurobiology, pathway, school of medicine, southern california usc, stem cells, university of southern california, usc researchers