Longevinex reduces size of heart attack better than resveratrol: Study
December 28th, 2010 - 3:02 pm ICT by ANIWashington, Dec 28 (ANI): Scientists have found that Longevinex worked better at reducing the size of a heart attack better than resveratrol.
The study compared and contrasted the gene-switching pattern for both plain resveratrol and resveratrol in a matrix with other small molecules (Longevinex) following an induced blockage of circulation in excised animal hearts.
The NIH researchers found that plain resveratrol and Longevinex both protected heart tissues and reduced the size of a heart attack, as measured by the amount of scar tissue (fibrosis).
Longevinex reduced the size of a heart attack (from ~35percent without treatment to ~20percent scar tissue with treatment) while resveratrol (from ~35percent to ~24percent scar tissue), and reduced death of heart muscle cells (cardiomyocytes) from ~17percent without treatment to ~9percent with Longevinex (48percent reduction in cell death), compared to a decline from ~17percent to ~12percent with plain resveratrol (20percent reduction in cell death).
Longevinex also doubled the heart pumping pressure as compared to resveratrol. It also improved blood flow in the aorta more than resveratrol.
MicroRNA’s are short segments of RNA that turn off gene protein-making machinery (called gene expression) when microRNA meshes with messenger RNA.
Upon analysis, the study results revealed that Longevinex exerted the greatest influence over the top 25 significantly differentiated microRNA’s in rodent heart tissue.
Longevinex exceeded the effect of resveratrol in 15 of the 25 microRNA’s.
The study is published in PloS. (ANI)
- Stem cell patch may improve function after heart attack - Nov 16, 2010
- MicroRNAs could increase amputation risk in diabetics - Jan 13, 2011
- Micro-RNA that regulates insulin in obesity identified - Apr 01, 2011
- RNA-based drugs may prevent premature labour - Nov 16, 2010
- Stem cell injections shrink enlarged hearts, improve function - Mar 18, 2011
- How ovarian cancer resists chemotherapy - Mar 03, 2011
- Gene makes ovarian cancer resistant to chemotherapy - Mar 03, 2011
- New discovery shows promise against pancreatic cancer - Dec 16, 2010
- New molecule may save brain cells from neurodegeneration, stroke - Jan 19, 2011
- Key enzyme in melanoma cell development found - Jun 18, 2010
- Gene variant role in Parkinson's discovered - Aug 01, 2010
- Scientists discover cancer treatment in 'junk DNA' - Sep 29, 2010
- Boffins identify 'gas pedal', 'brake' for uncontrolled cell growth - Aug 02, 2010
- Study examines gene that may hold key to reducing spread of oral cancer - Jul 24, 2010
- Autism effects may be reversible - Apr 24, 2010
Tags: aorta, blood flow, cell death, gene expression, heart attack, heart muscle cells, heart tissue, longevinex, meshes, messenger rna, microrna, molecules, nih, nih researchers, resveratrol, rodent, scar tissue, segments, tissue fibrosis, tissues