Inflammation may be link between extreme sleep durations and poor health

February 2nd, 2009 - 5:28 pm ICT by ANI  

Washington, Feb 02 (ANI): A new study, led by an Indian-origin researcher, has shown that sleep duration is linked to changes in the levels of specific cytokines that are important in regulating inflammation.
The results of the study, conducted by Dr. Sanjay R. Patel, assistant professor of medicine at Case Western Reserve University in Cleveland, Ohio, and his colleagues, suggest that inflammation may be the pathway linking extreme sleep durations to an increased risk for disease.
In the study, the researchers found that each additional hour of self-reported sleep duration was associated with an eight-percent increase in C-reactive protein (CRP) levels and a seven-percent increase in interleukin-6 (IL-6), which are two inflammatory mediators.
On contrary, each hour of reduction in sleep measured objectively by polysomnography was associated with an eight-percent increase in tumour necrosis factor alpha, another pro-inflammatory cytokine.
“The most surprising finding was that we found different relationships based on how sleep was measured,” said Patel.
According to the researchers, their study has linked both short and long sleep durations with an increased risk for mortality, coronary heart disease, diabetes and obesity.
Chronic elevations in cytokines such as CRP and IL-6 also are associated with an increased risk of problems such as diabetes and heart disease.
The study involved 614 individuals from the Cleveland Family Study, a longitudinal family-based epidemiological cohort designed to study the genetics of obstructive sleep apnea (OSA).
Participants completed questionnaires about sleep habits and underwent one night of polysomnography. In the morning a fasting blood sample was collected, and it was analyzed for five inflammatory cytokines.
Mean self-reported habitual sleep duration was 7.6 hours; mean sleep duration measured by polysomnography on the night prior to blood sampling was 6.2 hours.
Those with long sleep durations, assessed by either measure, were significantly younger. Short sleep duration measured by polysomnography was associated with an increased prevalence of diabetes, hypertension and obstructive sleep apnea.
According to the researchers, the differing patterns of association with cytokine levels suggest that self-reported habitual sleep duration may measure chronic sleep exposure, while polysomnography may measure an acute exposure.
They also note that the two methods of measuring sleep duration may be influenced differently by an underlying predictor of sleep habits such as stress or mood, which may have a direct effect on cytokine levels.
The study is published in the February issue of the journal SLEEP. (ANI)

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