How growth hormone can promote muscle growth
October 2nd, 2010 - 3:21 pm ICT by ANIWashington, Oct 2 (ANI): Growth hormone is not only used for children’s growth disorders, but is also being used by some sports men and women to promote muscle growth and regeneration.
This is because it coordinates skeletal muscle development, nutrient uptake, and nutrient utilization.
However, it is not clear which of these effects are direct and which are indirectly mediated via growth hormone induction of the protein IGF-1.
Now, however, a team of researchers, led by Thomas Clemens, at Johns Hopkins University School of Medicine, Baltimore, has used mice engineered to lack in their skeletal muscle either the molecule to which growth hormone binds or the molecule to which IGF-1 binds to show that growth hormone control of skeletal muscle development is dependent on IGF-1, whereas its control of nutrient uptake is independent of IGF-1.
The authors hope that with additional work, these results will guide more informed use of growth hormone or growth hormone analogs for promoting muscle development and reducing muscle loss. (ANI)
- How hormonal and molecular responses to exercise differ by age - Jan 26, 2011
- Putting ice on injuries could slow down healing process - Oct 27, 2010
- Potential new non-insulin treatment for type 1 diabetes found - Mar 25, 2011
- Growth defects in patients with cystic fibrosis 'may start before birth' - Nov 10, 2010
- Placing ice on injury may prevent healing - Oct 27, 2010
- Novel hydrogel regenerates burnt skin tissues - Dec 14, 2011
- Now, a tiny white bread mint like capsule to track cancer in the body - Mar 16, 2011
- Protein study sheds light on insulin response and cancer cell growth - Nov 06, 2010
- Inflammation post injury 'helps to heal damaged muscle tissue' - Oct 05, 2010
- Anticipation of sweets 'causes muscles to start taking up more blood sugar' - Dec 02, 2009
- Study: Ice on injury may prevent healing - Oct 27, 2010
- Bones may have bigger role in diabetes than believed - Jul 23, 2010
- Drug to reverse muscle loss due to cancer created - Aug 20, 2010
- Possible biomarker and therapeutic target for melanoma identified - Mar 18, 2011
- Potential therapeutic target for improving long-term memory identified - Jan 27, 2011
Tags: analogs, clemens, growth disorders, growth hormone, hormone induction, igf 1, johns hopkins university, johns hopkins university school, johns hopkins university school of medicine, men and women, mice, molecule, muscle growth, muscle loss, nutrient uptake, nutrient utilization, regeneration, school of medicine, skeletal muscle development, sports men
