How eating less can help boost lifespanJune 25th, 2009 - 1:51 pm ICT by ANI
London, June 25 (ANI): Scientists have long known that a restricted diet extends life. Now, researchers at the Salk Institute for Biological Studies have identified two enzymes that provide a new molecular explanation for how eating less leads to living longer.
Howard Hughes Medical Institute investigator Andrew Dillin and colleagues identified two proteins, WWP-1 and UBC-18, that link dietary restriction to longevity in roundworms.
Dillin says when researchers removed the two enzymes from the test animals, the benefits of a restricted diet disappeared.
And when those enzymes were enhanced, longevity and disease resistance increased.
The scientists say understanding how these molecules influence longevity could have implications for developing new treatments for age-related diseases.
“The only other known factor regulating longevity in response to diet restriction operates at the very end of the signaling cascade,” said Howard Hughes Medical Investigator and senior author Andrew Dillin, Ph.D., an associate professor in the Molecular and Cell Biology Laboratory.
“These two enzymes are further up the ladder, bringing us closer to the receptor that receives the signal for throwing the switch to promote a healthy lifespan,” Dillin added.
The study has been published in the June 24, 2009, advance online edition of the journal Nature. (ANI)
- Scientists find binary switch that turns 'aging process on and off' - Feb 17, 2011
- How slowing the engines of mitochondria extends lifespan - Jan 07, 2011
- New clue into cellular aging identified - Jul 08, 2010
- Why a low cal diet can help you live longer - Jul 16, 2010
- Fewer calories spell longer life, protection from diabetes - Nov 01, 2011
- Blocking rogue gene could stop cancer - Jan 25, 2011
- Blocking rogue gene could halt the spread of most cancers - Jan 25, 2011
- Extend youthfulness to keep Alzheimer's at bay - Dec 11, 2009
- Molecular trigger that helps prevent aging and disease found - Nov 19, 2009
- Aging-related protein holds breast cancer clues - Jan 28, 2011
- Brain molecules linked to long-term memories discovered - Mar 21, 2011
- Fasting develops smarter brain, shapelier you - Feb 20, 2012
- Fight age, go on a diet - Nov 19, 2009
- Low calorie diet doesn't add to longevity - Aug 31, 2012
- Study sheds light on mutations in genetic pathways that extend lifespan in animals - Jun 08, 2009
Tags: andrew dillin, associate professor, cell biology laboratory, dietary restriction, disease resistance, enzymes, howard hughes, howard hughes medical, howard hughes medical institute, hughes medical institute, journal nature, lifespan, longevity, medical investigator, molecular and cell biology, salk institute for biological studies, test animals, throwing the switch, ubc, wwp