Hope for infertile men as scientists grow test-tube spermMarch 24th, 2011 - 12:54 pm ICT by ANI
London, Mar 24 (ANI): Japanese scientists have accomplished a feat thought to be impossible - for the first time, they have produced fertile mammalian sperm in a test tube.
The technique holds significant promise for male infertility, reports Nature.
Biologists have been trying to make sperm outside the body for almost a century.
So, a team led by Takehiko Ogawa of Yokohama City University designed a way to culture sperm and allow them to mature outside of the body.
They found that the key to getting sperm through meiosis lay in a simple change to standard culture conditions.
Ogawa and his colleagues took tissue fragments from neonatal mouse testes to mature.
They then soaked the testes tissue in a mixture called KnockOut Serum Replacement, often used to grow embryonic stem cells.
To track sperm development, they used a fluorescent protein that marked cells undergoing - or that had undergone - meiosis.
After several weeks in the mix, the testes looked normal and were producing sperm. Nearly half of the samples contained cells with sperm-like tails.
Finally, the researchers injected the sperm into egg cells. A few weeks later, surrogates delivered a dozen live, fertile offspring. (ANI)
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Tags: biologists, colleagues, culture conditions, egg cells, embryonic stem cells, fertile offspring, fragments, infertile men, infertility, japanese scientists, knockout, london, male infertility, mammalian sperm, mixture, ogawa, protein, serum, test tube, yokohama city university