High plasma levels of beta-amyloid linked with faster cognitive declineAugust 10th, 2010 - 1:32 pm ICT by ANI
Washington, August 10 (ANI): A new study has found that high plasma levels of beta-amyloid -protein fragments associated with Alzheimer’s disease when they accumulate in the brain- appear to be associated with faster cognitive decline even in those who do not develop dementia.
The amyloid cascade hypothesis suggests that Alzheimer’s disease develops when the body is unable to metabolise glycoproteins, the precursors to amyloid, according to background information in the article.
Beta-amyloid 40 and beta-amyloid 42 then accumulate, and this accumulation is considered the primary trigger for the development of Alzheimer’s disease.
Dr. Stephanie A. Cosentino of Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, and colleagues studied 880 individuals who were free of dementia at the beginning of the study and who had at least two plasma beta-amyloid measurements approximately four and one-half years apart.
Participants were assessed for cognitive change using an overall thinking, learning and memory score as well as in separate memory, language and visuospatial domains.
Between the two beta-amyloid measurements, 481 participants remained cognitively healthy, 329 were cognitively or functionally impaired but did not have dementia and 70 developed Alzheimer’s disease.
High plasma beta-amyloid levels at the beginning of the study, along with decreasing or relatively stable values over time, were associated with faster cognitive declines in multiple domains.
The link persisted even when only those who did not develop dementia were analyzed.
“Examination of specific cognitive domains in the current study revealed that global cognitive change in healthy elderly individuals was driven primarily by memory, rather than language or visuospatial abilities,” wrote the authors.
“This seemingly selective association with memory has several interpretations. First, it may suggest that healthy elderly people with a high-risk beta-amyloid profile are in the early stages of Alzheimer’s disease but have not yet demonstrated sufficient change in non-memory domains to meet criteria for dementia,” they added.
The report will be posted online and will appear in the December print issue of Archives of Neurology, one of the JAMA/Archives journals. (ANI)
- Potent new vaccine found effective against Alzheimer's - Jun 08, 2012
- Alzheimer's hits women more severely than men - Aug 26, 2012
- High levels of 'good' cholesterol linked to lower risk of Alzheimer's - Dec 14, 2010
- Proteins responsible for Alzheimer's 'may spread through infection' - Oct 22, 2010
- Eating foods rich in vitamin E 'lowers dementia risk' - Jul 13, 2010
- Novel radiotracer raises hopes of easy Alzheimer's diagnosis - Jun 25, 2010
- Lots of nuts, poultry and less of red meat, butter 'can cut Alzheimer's risk' - Apr 13, 2010
- Cellphone use can protect against Alzheimer's disease - Jan 07, 2010
- 'Vitamin C keeps dementia at bay' - Sep 12, 2012
- Now, 3 biomarkers in spinal fluid could classify patients with Alzheimer's - Aug 10, 2010
- Changes in walking speed could signal dementia - Jun 12, 2012
- Chronic high cholesterol diet leads to brain damage: Study - Nov 25, 2010
- Tobacco-derived compound prevents memory loss in Alzheimer's - Apr 28, 2011
- Sleep disorders are early signs of Alzheimer's - Sep 06, 2012
- Scientists eliminate plaque formation in Alzheimer's - Sep 06, 2012
Tags: aging brain, amyloid protein, beta amyloid, cognitive change, cognitive decline, cognitive domains, columbia university medical, cosentino, dementia, elderly individuals, learning and memory, memory language, plasma levels, precursors, protein fragments, selective association, stable values, taub institute, university medical center, visuospatial abilities