High-fat diet can disrupt bodys biological clockDecember 30th, 2008 - 11:27 am ICT by ANI
Washington, Dec 30 (ANI): Heres another reason to avoid high-fat diet it can disrupt our biological clock, say researchers.
According to Hebrew University of Jerusalem researchers, indulgence in a high-fat diet can not only lead to overweight because of excessive calorie intake, but also can affect the balance of circadian rhythms everyone’’s 24-hour biological clock.
The biological clock regulates the expression and/or activity of enzymes and hormones involved in metabolism, and disturbance of the clock can lead to such phenomena as hormone imbalance, obesity, psychological and sleep disorders and cancer.
While light is the strongest factor affecting the circadian clock, Dr. Oren Froy and his colleagues of the Institute of Biochemistry, Food Science and Nutrition at the Hebrew University’’s Robert H. Smith Faculty of Agriculture, Food and Environment in Rehovot, have demonstrated in their experiments with laboratory mice that there is a cause-and-effect relation between diet and biological clock imbalance.
To reach the conclusion, Froy and his colleagues, Ph.D. student Maayan Barnea and Zecharia Madar, the Karl Bach Professor of Agricultural Biochemistry, tested whether the clock controls the adiponectin signaling pathway in the liver and, if so, how fasting and a high-fat diet affect this control.
Adiponectin is secreted from differentiated adipocytes (fat tissue) and is involved in glucose and lipid metabolism. It increases fatty acid oxidation and promotes insulin sensitivity, two highly important factors in maintaining proper metabolism.
The researchers fed mice either a low-fat or a high-fat diet, followed by a fasting day, then measured components of the adiponectin metabolic pathway at various levels of activity. In mice on the low-fat diet, the adiponectin signaling pathway components exhibited normal circadian rhythmicity. Fasting resulted in a phase advance.
The high-fat diet resulted in a phase delay. Fasting raised and the high-fat diet reduced adenosine monophosphate-activated protein kinase (AMPK) levels. This protein is involved in fatty acid metabolism, which could be disrupted by the lower levels.
In an article, which will be published by the journal Endocrinology, the researchers suggest that this high-fat diet could contribute to obesity, not only through its high caloric content, but also by disrupting the phases and daily rhythm of clock genes.
They contend also that high fat-induced changes in the clock and the adiponectin signaling pathway may help explain the disruption of other clock-controlled systems associated with metabolic disorders, such as blood pressure levels and the sleep/wake cycle. (ANI)
- Birch bark ingredient has an array of metabolic benefits - Jan 05, 2011
- Round-the-clock lifestyle affects metabolism, behaviour - Feb 28, 2011
- Childhood obesity could erode fertility later - Aug 01, 2012
- Low fat, fish oil diet helps slow down cancer - Oct 26, 2011
- What babies eat determines risk of obesity - Aug 31, 2012
- Apple compound may help burn fat, reduce obesity - Jun 21, 2012
- Why fatty diets during pregnancy make kids obese - Nov 23, 2010
- Soy protein can lower fat accumulation in liver - Apr 23, 2012
- A rhythm awry means rolls of fat - Aug 30, 2012
- New mechanism regulating body's 24-hour clock identified - Nov 12, 2010
- How fat hormone guards against stress-induced heart damage - Nov 02, 2010
- Circadian clock genes control appetite, consumption in fruit flies - Dec 07, 2009
- Short-term, high-fat diet 'may cut heart attack damage' - Apr 14, 2011
- Disruption in body clock genes could lead to diabetes - Jul 14, 2010
- High-fat diet lowers blood sugar in diabetics - May 13, 2012
Tags: adiponectin, agricultural biochemistry, biological clock, circadian clock, circadian rhythms, faculty of agriculture, fatty acid oxidation, food science and nutrition, froy, hebrew university of jerusalem, insulin sensitivity, karl bach, laboratory mice, lipid metabolism, low fat diet, metabolic pathway, phase advance, proper metabolism, robert h smith, smith faculty