Heart protein helps save skeletal musclesMay 26th, 2009 - 2:25 pm ICT by ANI
Washington, May 26 (ANI): A new study has shown that a heart muscle protein can compensate for its missing skeletal muscle counterpart to give mice suffering from muscular disease an active life.
It also increased the long-term survival of the study mice.
The contraction machinery protein, actin, exists in different forms in the adult heart and skeletal muscles.
The heart form, ACTC, is the dominant form in skeletal muscle of the fetus.
However during development, the skeletal form, ACTA1, increases in production and by birth has taken over.
The researchers suggested that mutations to the ACTA1 gene cause a rare but serious myopathy or muscular disease.Most patients die within the first year of life and some are born almost completely paralyzed.
Lead researcher Nowak showed that mice lacking ACTA1 died within nine days after birth.
The team sought to determine if ACTC could compensate for a lack of ACTA1.
They crossed Acta1 mutant mice with transgenic mice that express human ACTC at high levels in skeletal muscle cells.
The resulting mice didn’t die at nine days. In fact, almost 93.5pct survived more than three months, and some more than two years.
Moreover the mice’s locomotor performance was comparable with wild-type, as was their overall muscle strength and their endurance was actually higher-they ran faster and for longer.
The findings were published in the Journal of Cell Biology. (ANI)
- Cure found for muscle disease that kills millions of kids - May 26, 2009
- Breakthrough in 'floppy baby' syndrome - May 26, 2009
- New approach could reverse liver failure - Aug 06, 2012
- Chemical in soap, toothpaste impairs muscle strength - Aug 14, 2012
- Novel discovery could help in early identification of muscular dystrophy - Jun 17, 2009
- How growth hormone can promote muscle growth - Oct 02, 2010
- Protein that could be new target to reduce damage after heart attack identified - Feb 25, 2011
- Cause of fatal inflammation of the heart muscle found - Mar 30, 2011
- Human protein slows muscle damage in muscular dystrophy mice - Dec 28, 2010
- Burning brown fat could be the key to tackling obesity - Dec 21, 2010
- Missing protein helps mice on high-fat diet stay slim - Apr 16, 2010
- Scientists reverse muscle wasting due to cancer in mice - Aug 24, 2010
- Protein linked with heart failure discovered - May 24, 2011
- Researchers discover protein that contributes to a healthy heart - Nov 26, 2009
- Burning more sugar drives super athleticism - Dec 01, 2011
Tags: actc, active life, adult heart, contraction, fetus, heart muscle, journal of cell biology, locomotor, muscle protein, muscle strength, muscular disease, mutant mice, myopathy, nine days, nowak, protein actin, skeletal muscle cells, skeletal muscles, term survival, transgenic mice