Growth defects in patients with cystic fibrosis ‘may start before birth’November 10th, 2010 - 2:55 pm ICT by ANI
Washington, Nov 10 (ANI): A new study by University of Iowa researchers, using a pig model of cystic fibrosis (CF), has suggested that low levels of a growth promoting hormone at or before birth may contribute to growth defects in patients with cystic fibrosis.
The study could help predict the severity of the disease in patients and may lead to new therapies for growth defects in people with CF.
Growth defects are common in people with CF and have been blamed, in part, on low levels of the growth-promoting hormone called insulin-like growth factor 1 (IGF1).
Traditionally, the malnutrition and lung inflammation that accompany CF have been blamed for the decreased levels of IGF1. However, even patients who are relatively healthy often do not reach their full growth potential, and newborns with CF often are smaller at birth than healthy babies.
To investigate the relationship between neonatal IGF1 levels and growth patterns in CF, the research team studied newborn pigs with a CF-causing gene mutation. This animal model, which was generated by the UI researchers and colleagues at the University of Missouri in 2008, has many of the same symptoms and complications that are seen in humans with CF.
“By examining IGF1 at this time point, we eliminated consequences of lung inflammation, which is absent at birth, and malnutrition, because nutrition in utero is provided by the mother,” explained Leah Reznikov, UI postdoctoral fellow in internal medicine and co-first author of the study.
“We found that IGF1 levels were significantly reduced at birth in CF newborn pigs.”
In addition, the UI researchers found that newborn CF pigs had shorter, smaller bones than pigs without CF suggesting that decreased IGF1 levels are associated with the growth defects, and that IGF1 levels may be reduced even before the pigs are born.
“Collectively, these findings suggest that IGF1 deficits begin very early in the course of CF disease and reductions in IGF1 may, in part, explain growth defects observed at birth in infants with CF,” Reznikov said.
“The findings also imply that IGF1 may serve as a potential biomarker of the disease and may be useful in prognostication, care and treatment of people with CF.”
The study has been published online in the Early Edition of the Proceedings of the National Academy of Sciences. (ANI)
- Boffins come closer to understanding how cystic fibrosis causes lung disease - Apr 29, 2010
- Novel drug may benefit cystic fibrosis patients - Dec 18, 2010
- Protein involved in cystic fibrosis linked to chronic lung diseases - Dec 30, 2010
- Drug targets defective protein that causes cystic fibrosis - Nov 18, 2010
- Crosstalk between ion channels leads to new therapeutic strategy - Sep 20, 2010
- New bacterial foe in cystic fibrosis identified - Oct 02, 2010
- Infliximab treatment effective for cystic fibrosis and Crohn's disease - Apr 20, 2010
- Human lungs can sweep out intruders - Aug 26, 2012
- Scientists one step closer to a drug treatment for cystic fibrosis - Oct 13, 2010
- Vitamin D may prevent or treat allergy to common mould - Aug 17, 2010
- Vitamin D may treat allergy to common mold - Aug 26, 2010
- Putting ice on injuries could slow down healing process - Oct 27, 2010
- Diabetic women likely to deliver babies with defects - Feb 06, 2012
- Nutrition-starved bugs become resistant to antibiotics - Nov 18, 2011
- Placing ice on injury may prevent healing - Oct 27, 2010
Tags: animal model, cystic fibrosis, gene mutation, growth factor 1, growth patterns, igf1, insulin like growth factor, internal medicine, iowa researchers, lung inflammation, malnutrition, newborn pigs, newborns, reznikov, severity, time point, ui researchers, university of iowa, university of missouri, utero