Genetic ancestry has no effect on asthma response in African AmericansSeptember 28th, 2010 - 4:13 pm ICT by ANI
Washington, Sep 28 (ANI): Genetic ancestry has no role to play in how African American patients with asthma respond to medication, according to a Henry Ford Hospital study.
Researchers found that improved lung function in patients after taking inhaled steroids was related to a series of baseline breathing function measures, not genetic ancestry.
Advances in genetics have led to the development of ancestry markers spread across the human genome, which allow genetic ancestry to be easily and inexpensively estimated among African Americans.
It has the potential to be a useful tool in predicting the severity of common conditions among African Americans and fostering the development for more personalized medicine.
“However, our study found that genetic differences due to ancestry probably contributed to little, if any, difference in how African Americans responded to inhaled corticosteroids,” said Dr. Wendy Gould, the study’s lead author.
African Americans appear to be especially prone to asthma and its complications, which result in more frequent emergency department visits and hospitalizations when compared with white individuals.
Because of that susceptibility, Henry Ford researchers set out to determine what role, if any, genetic ancestry plays in how well African Americans respond to inhaled corticosteroids, which is considered the most effective class of medication for controlling asthma.
Researchers followed 147 African-American asthma patients aged 12-56 who were treated with inhaled steroids for six weeks.
Their breathing function was tested before and after the six-week treatment protocol. Genetic testing was done on DNA isolated from a single blood sample.
“This is one of the first studies to use genetic ancestry to help clarify whether response to medication differs from race or ethnic groups. Fortunately, our results suggest that this potentially life-saving asthma medication is equally beneficial across groups,” said Dr. Keoki Williams, the study’s senior author.
The study is published online at the Journal of Allergy and Clinical Immunology. (ANI)
- Regular medication can ease severe asthma attacks - Jan 03, 2012
- Mild asthma might not need to be treated every day: Study - Feb 15, 2011
- Inhaled steroids up diabetes risk: Study - Nov 02, 2010
- Now, alternate therapy for adults with poorly controlled asthma - Sep 20, 2010
- Low vitamin D levels linked to lower lung function in asthmatic kids - Apr 16, 2010
- Asthmic kids on steroids grow slightly shorter - Sep 04, 2012
- Racial disparities in head, neck cancer more to do with society than biology - Sep 27, 2010
- Being obese doesn't worsen asthma - Jun 04, 2009
- Combo inhaler may simplify asthma treatment - Apr 15, 2009
- Allergy shots beneficial for some asthmatics, risky for others - Aug 09, 2010
- Inhaled corticosteroids may increase diabetes risk - Dec 15, 2010
- Educational home visits may improve asthma symptoms in kids - Dec 01, 2009
- Post-transplant patients off steroids have fewer cardiovascular events - May 08, 2010
- Health Warning issued for certain Asthma Drugs - Feb 20, 2010
- Experimental non-steroidal treatment of asthma holds promise - Jul 02, 2010
Tags: advances in genetics, african american patients, african americans, ancestry, asthma medication, asthma patients, blood sample, breathing function, dr wendy, emergency department visits, genetic differences, genetic testing, henry ford, henry ford hospital, human genome, inhaled corticosteroids, inhaled steroids, lung function, study researchers, treatment protocol