Gene linked to canine compulsive disorder identifiedJanuary 7th, 2010 - 2:35 pm ICT by ANI
Washington, Jan 7 (ANI): An international team of scientists claim to have identified the gene that appears to play a vital role in compulsive disorder in dogs.
Obsessive compulsive disorder is characterized by time consuming, repetitive behaviours and affects about 2 percent of humans, while the equally distressing canine equivalent, canine compulsive disorder, or CCD, seems to target certain dog breeds, especially Dobermans and Bull Terriers.
Lead researchers Dodman and Moon-Fanelli have found that a canine chromosome 7 locus confers a high risk of compulsive disorder susceptibility.
The chromosome 7 location most significantly associated with CCD is located within the neural cadherin-2 gene, CDH2.
“The CDH2 gene is expressed in the hippocampus, a brain region suspected to be involved in OCD. In addition, this gene oversees structures and processes that are possibly instrumental in propagating compulsive behaviors - for example, the formation and proper functioning of glutamate receptors,” said Dr. Nicholas Dodman, professor of clinical sciences at Cummings School of Veterinary Medicine at Tufts University and the study’s lead author.
“The occurrence of repetitive behaviours and similarities in response to drug treatments in both canine CCD and human OCD suggest that common pathways are involved” said Dr. Ginns, professor of Clinical Pathology, Neurology, Pediatrics, Psychiatry and Neuroscience at UMass Medical School.
Dr. Ginns is hopeful that “our finding will lead to a better understanding of the biology of compulsive disorder and facilitate development of genetic tests, enabling earlier interventions and even treatment or prevention of compulsive disorders in at-risk canines and humans.”
The findings are published in Molecular Psychiatry. (ANI)
- Gene behind Canine Compulsive Disorder identified - Jan 10, 2010
- Early treatment can cure compulsive handwashing - Apr 04, 2011
- Excessive ritualism linked to mental disorder - Dec 29, 2011
- What can sportsmen, OCD patients have in common? - Sep 22, 2011
- Kidney disease gene linked to debilitating mental disorder - Jan 05, 2011
- Anxiety disorder common in people with Tourette syndrome - Jun 18, 2010
- Emily Blunt's OCD fears - Jun 21, 2012
- Brain chemical linked to obsessive compulsive disorder found - Apr 27, 2010
- British dogs to get anti-depressants - Jun 25, 2012
- Clutter hoarding may run in one's family - Sep 26, 2009
- Military Bomb Sniffing Dog Named 'Gina' Diagnosed With PTSD - Aug 05, 2010
- Genes trigger roots of bipolar disorder? - Sep 02, 2012
- Now, anti-depressant pill just for dogs! - Feb 21, 2010
- Risk factor for obsessive-compulsive disorder identified - May 29, 2009
- Deep brain stimulation 'can treat severe OCD' - Feb 19, 2011
Tags: brain region, bull terriers, cadherin, chromosome 7, clinical pathology, compulsive behaviors, compulsive disorder in dogs, compulsive disorders, dog breeds, dr nicholas, genetic tests, ginns, glutamate receptors, molecular psychiatry, nicholas dodman, obsessive compulsive disorder, repetitive behaviours, school dr, school of veterinary medicine, tufts university