Gene fusion linked to cancer developmentJanuary 12th, 2009 - 1:05 pm ICT by ANI
London, Jan 12 (ANI): Researchers at the University of Michigan Comprehensive Cancer Centre have identified a series of gene fusions that might one day serve as a marker for detecting cancer.
Recurrent gene fusions are believed to be the mechanism that leads to cancer development.
The research team claim that they have discovered several gene fusions in prostate cancer cells.
These fusions occur when chromosomes, the packages of DNA that contain genes, switch places with each other.
“We defined a new class of mutations in prostate cancer. The recurrent fusions are thought to be the driving mechanism of cancer, Nature magazine quoted Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology and S.P. Hicks Endowed Professor of Pathology at the U-M Medical School, as saying.
But we found other fusions as well, some of which were unique to individual patients. Our next step is to understand if these play a role in driving disease,” he added.
Gene fusions are already known to play a role in blood cell cancers such as leukaemia and lymphoma, and Ewing’’s sarcoma, a rare bone disease. (ANI)
- Potential driver of some aggressive prostate cancers found - Apr 05, 2011
- Drug for rare childhood cancer may help prevent prostate cancer spread - Apr 30, 2011
- Gene fusion is the 'smoking gun' in the development of prostate cancer: Study - May 19, 2010
- How 'triggering event' in cancer occurs - Oct 30, 2009
- Scientists reveal prostate cancer's multiple personalities - Nov 04, 2010
- Gene mutation behind onset of acute myeloid leukaemia identified - Mar 28, 2011
- Genetic markers could help detect early prostate cancer onset - Jun 08, 2010
- Mechanism that turns healthy cells into prostate cancer cells discovered - Dec 03, 2010
- Full genetic blueprint of multiple prostate tumors unveiled - Feb 10, 2011
- 'Junk' DNA behind cancer growth - May 03, 2010
- Simple urine test may detect aggressive prostate cancer - Feb 12, 2009
- Scientists complete whole-exome sequencing of skin cancer - Apr 16, 2011
- How dietary supplement could block cancer cells - Jun 30, 2010
- Molecular predictor of metastatic prostate cancer identified - Feb 03, 2011
- Inflammation may provide breeding ground for cancer - Apr 20, 2011
Tags: blood cell, cancer development, cell cancers, chromosomes, comprehensive cancer centre, ewing, fusions, gene fusion, leukaemia, london jan, m medical school, michigan center, michigan comprehensive cancer, mutations, nature magazine, prostate cancer, prostate cancer cells, rare bone disease, switch places, translational