Frogs provide clues about alcohol’s effects during pregnancy
April 6th, 2009 - 2:12 pm ICT by ANI ( Leave a comment )Washington, Apr 6 (ANI): Scientists have successfully used the African frog Xenopus as a tool to identify important clues about the effects of maternal consumption of alcohol in early pregnancy.
As the Xenopus embryos are large, easy to work with and very responsive to environmental cues, they make for ideal instruments to understand early vertebrate development.
Foetal alcohol spectrum disorder (FASD) and Foetal alcohol syndrome (FAS) cause malformations in babies, including facial defects, short stature, and mental and behavioural abnormalities.
Alcohol consumption prevents normal development by inhibiting the production of retinoic acid.
Normally, the levels of retinoic acid made in different areas of the embryo provide cells with necessary information about their proper location and fate.
In the new research, it has been shown that alcohol steals away the molecules that make retinoic acid and use them for its own process of detoxification, resulting in cellular disorientation during a critical period of development.
The study, provides evidence that the characteristics associated with FASD and FAS come from competition of alcohol for key molecules in a pathway that produce retinoic acid from vitamin A.
Retinoic acid is needed for correct positioning of cells in developing embryos and by preventing its normal production.
Alcohol keeps cells from migrating to their correct positions and maturing properly.
Researchers at the Hebrew University in Israel have found that shutting down a molecule needed to produce retinoic acid, known as retinaldehyde dehydrogenase (RALDH2), increases sensitivity of developing embryos to low doses of alcohol.
On the other hand, more of the molecule RALDH2 protected embryos from the negative effects of alcohol.
The research provides evidence that alcohol ‘hijacks’ RALDH2 molecules for its own breakdown process, and steals it away from its important role in synthesizing positional and maturation cues during development.
The study has been published in Disease Models & Mechanisms (DMM). (ANI)
- Scientists uncover mechanism that may help fight birth defects - Jun 10, 2009
- Study on frogs and fish sheds light on human hearing - Mar 20, 2011
- Effect of alcohol on foetus development not clear, say researchers - Jun 17, 2010
- Frog embryos may harbour human heart health secrets - Apr 24, 2011
- Fetal alcohol exposure linked to a decrease in cognitive performance - Oct 20, 2010
- Carrots can help prevent breast cancer - Apr 06, 2011
- New study focuses on cause of celiac disease - Feb 10, 2011
- A vaccine that gives you hangover to help quit liquor! - Jan 09, 2011
- Root cause of blood vessel damage in people with diabetes discovered - Jan 29, 2011
- Vitamin A plays key role in the human body - Mar 18, 2011
- New booze vaccine works by 'giving terrible hangover just after 1 drink' - Jan 08, 2011
- Male foetuses more vulnerable to alcohol - Mar 24, 2011
- Trio of drugs may help fight 'triple negative' breast cancer - Dec 11, 2010
- 'Anti-social' attitude in boozy fish may explain alcoholism impact in humans - Feb 14, 2011
- Hangovers 'only get worse with age' - Mar 18, 2011
Tags: alcohol consumption, alcohol in early pregnancy, alcohol syndrome, correct positions, critical period, cues, detoxification, disorientation, effects of alcohol, facial defects, fasd, frog xenopus, hebrew university, molecule, negative effects of alcohol, proper location, short stature, spectrum disorder, vertebrate development, xenopus embryos
