Drug used to treat type 2 diabetes linked to heart problemsMarch 18th, 2011 - 1:49 pm ICT by ANI
London, March 18 (ANI): A new study has added to mounting evidence that rosiglitazone - a drug used to treat type 2 diabetes - is associated with an increased risk of major heart problems.
It has found that rosiglitazone is associated with significantly higher odds of congestive heart failure, heart attack and death compared with a similar drug (pioglitazone).
Rosiglitazone and pioglitazone belong to a class of drugs called thiazolidinediones that help to control blood sugar levels in patients with type 2 diabetes. Both drugs are known to increase the risk of heart failure, but it is unclear whether there are clinically important differences in their cardiac safety.
So a team of researchers in the UK and the US set out to compare the cardiovascular effects of the two drugs among patients with type 2 diabetes.
They analysed the results of 16 studies involving 810,000 patients (429,000 on rosiglitazone and 381,000 on pioglitazone). Most patients were aged over 60 years.
Compared with pioglitazone, rosiglitazone was associated with a modest but statistically significant increased risk of heart attack (16 pc), congestive heart failure (23 pc), and mortality (14 pc).
In certain groups of patients with type 2 diabetes, this may lead to 170 excess heart attacks, 649 excess cases of heart failure, and 431 excess deaths for every 100,000 patients who receive rosiglitazone rather than pioglitazone.
Further adjusting the data to minimise bias, did not change the results significantly, suggesting that this is unlikely to be a chance finding, said the authors.
“Our findings have important implications,” they wrote.
“Rosiglitazone is still available on a restricted basis in the United States and Canada. However, for patients who need thiazolidinedione treatment, continued use of rosiglitazone may lead to excess heart attacks, heart failure and mortality, compared with pioglitazone.”
The study has been published on bmj.com. (ANI)
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