Damaged stem cells ”ignite bowel cancer development: StudyDecember 21st, 2008 - 5:06 pm ICT by ANI
London, Dec 21 (ANI): UK and Dutch scientists may be narrowing down the hunt for cells that are the primary source of bowel cancer.
The scientists found, when genetic damage was inflicted on stem cells from the intestines of mice, the result was a speedy transformation into fast-growing tumours.
The experts reckon that the discovery, reported in the journal Nature, could make it easier to target and prevent the disease.
Researchers want to know what event causes a normal, healthy bowel cell to turn cancerous and start to form tumours.
To reach the conclusion, researchers at the Beatson Institute in Glasgow, Cardiff University, along with scientists at Hubrecht Institute in the Netherlands, isolated intestinal stem cells in mice, then “knocked out” a specific gene called APC from them.
The APC gene is described as a “tumour suppressor gene” and plays a role in regulating the way a cell divides, reports the BBC.
Within days, the stem cell populations had started to form tumours. When the same technique was applied to non-stem cell “daughter” cells, far fewer tumours were formed.
Professor Hans Clevers, from the Hubrecht Institute, said: “We are very excited by these findings but we need to establish whether the stem cells will behave the same way in human cancers as they do in mice.”
Dr Owen Sansom, from the Beatson Institute, added: “We are now looking to understand how we can use these results to seek out and destroy stem cells that are lacking the APC gene.” (ANI)
- Red meat could elevate bowel cancer risk - Aug 10, 2012
- Intestinal stem cells offer clues to colon cancer origin and relapse - Mar 18, 2011
- Fish oil may hold key to leukaemia cure - Dec 23, 2011
- Even a minor cut 'can trigger tumour' - Feb 15, 2011
- Black raspberries 'highly effective in preventing colorectal cancer' - Nov 03, 2010
- Scientists bring cancer cells back under normal control - Jan 19, 2011
- New discovery could stop stem-cell loss during cancer therapy - Sep 06, 2010
- Mechanism for esophageal cancer identified - Apr 12, 2011
- DNA test to detect early bowel cancer could be 1 step closer - Mar 05, 2011
- Cell suicide can trigger cancer growth - Aug 02, 2010
- DNA damage can help protect the body from infection - Apr 01, 2011
- Protein that controls liver stem cells, prevents tumor development found - Aug 13, 2010
- Scientists find molecular switch that controls skin growth - Mar 04, 2011
- Scientists create new tool to understand how cancers grow - Feb 21, 2010
- Scientists turn stem cells into intestinal tissue for the first time - Dec 13, 2010
Tags: apc gene, beatson institute, bowel cancer, cancer development, cardiff university, cell populations, clevers, daughter cells, disease researchers, dr owen, dutch scientists, genetic damage, human cancers, intestines, journal nature, primary source, sansom, stem cells, suppressor gene, tumours