Cutaneous application of nanoparticles may help treat erectile dysfunction

April 27th, 2009 - 12:08 pm ICT by ANI  

Washington, Apr 27 (ANI): New York scientists have found that cutaneous application of nanoparticles, could offer a new means of delivering drugs to treat erectile dysfunction (ED).

The findings have revealed that topical treatments for ED could provide localized therapeutic results with the benefit of lower dosage and the avoidance of adverse side effects due to systemic absorption.

For the study, the researchers investigated a novel hybrid hydrogel/glass nanoparticle platform.

They developed nanoparticles capable of sustained release of therapeutic levels of nitric oxide (NO), which aids in erection biology and relaxes smooth muscle cells in the penis.

They then applied these nanoparticles to the skin of the penis of seven rats, and measured erectile response by intracorporal pressure/blood pressure (ICP/BP) ratio.

It was found that out of the seven animals treated with NO releasing nanoparticles, five experienced positive effects on the ICP/BC, resulting in a visible erection.

The average time for an erectile response was found to be approximately 65 minutes.

“This is a very interesting concept which has potential to impact treatment of many conditions including erectile dysfunction if it can be translated from the animal lab to clinical practice. It remains to be seen whether the effect of the nanoparticle technology is a local or a systemic effect, ” said Ira D. Sharlip, MD, an AUA spokesman.

The study was presented at the 104th Annual Scientific Meeting of the American Urological Association (AUA). (ANI)

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