Common virus may cause high blood pressureMay 15th, 2009 - 1:55 pm ICT by ANI
Washington, May 15 (ANI): A common virus affecting 60 to 99 percent of adults worldwide can be a major cause of high blood pressure, finds a new study.
The research team from Beth Israel Deaconess Medical Center (BIDMC) showed that when combined with other risk factors for heart disease, the cytomegalovirus (CMV), can lead to the development of atherosclerosis, or hardening of the arteries.
“CMV infects humans all over the world,” said co-senior author Dr Clyde Crumpacker, an investigator in the Division of Infectious Diseases at BIDMC and Professor of Medicine at Harvard Medical School.
“This new discovery may eventually provide doctors with a whole new approach to treating hypertension, with anti-viral therapies or vaccines becoming part of the prescription,” Crumpacker added.
CMV affects all age groups and is the source of congenital infection, mononucleosis, and severe infection in transplant patients.
In the study using mouse models, the scientists examined four groups of laboratory mice.
Two groups of animals were fed a standard diet and two groups were fed a high cholesterol diet. After a period of four weeks, one standard diet mouse group and one high-cholesterol diet mouse group were infected with the CMV virus.
They found that CMV-infected mice had increased blood pressure compared with the uninfected group.
Moreover, 30 percent of the CMV-infected mice that were fed a high-cholesterol diet not only exhibited increased blood pressure, but also showed signs of having developed atherosclerosis.
“This strongly suggests that the CMV infection and the high-cholesterol diet might be working together to cause atherosclerosis,” said Crumpacker.
A second analysis found that infection of a mouse kidney cell line with murine CMV led to an increase in expression of the renin enzyme, which has been known to activate the renin-angiotensin system and lead to high blood pressure. (ANI)
- Dormant virus might make you diabetic - Aug 28, 2012
- Diarrhea-causing bacteria turned into antiviral gene therapy agent - Feb 08, 2011
- Western diet 'ups prostate cancer risk' - Dec 02, 2010
- Tangerines help prevent obesity, protect against heart disease - Apr 07, 2011
- High fat diet damages arteries earlier than suspected - Apr 04, 2012
- Watermelon reduces hardening of arteries - Oct 28, 2011
- Gene linked to high cholesterol in blood found - Sep 16, 2010
- Targeting fatty acids in immune cells may cut atherosclerosis risk - Jul 24, 2010
- Low-carb diets may cause atherosclerosis, impaired blood vessel growth - Aug 25, 2009
- New cell therapy shows promise against atherosclerosis - Mar 02, 2011
- Human enzyme holds promise of weight loss - Nov 15, 2011
- Virus causes hearing loss among newborns - Jun 22, 2011
- Transparent zebrafish help scientists follow unfolding heart disease - Mar 06, 2009
- The humble red onion could help prevent heart disease - Oct 07, 2010
- Gut bug may cause development of Parkinson's - May 23, 2011
Tags: beth israel deaconess, beth israel deaconess medical, beth israel deaconess medical center, bidmc, cause of high blood pressure, cmv infection, cmv virus, congenital infection, cytomegalovirus cmv, deaconess medical center, hardening of the arteries, harvard medical school, high blood pressure, high cholesterol diet, israel deaconess medical center, laboratory mice, mouse models, new discovery, renin angiotensin system, risk factors for heart disease