Boffins identify genes contributing to skin disease that triggers hair loss
July 5th, 2010 - 6:18 pm ICT by ANIWashington, July 5 (ANI): American researchers have identified eight genes contributing to alopecia areata, an autoimmune skin disease that may result in total or partial loss of hair.
For the research, America’s National Alopecia Areata Foundation Scientific Advisory Council member Dr. Angela Christiano led a team of investigators from Columbia University Medical Center.
Part of the significance of this recent finding is that many of the genes found to be associated with alopecia areata are also associated with other autoimmune diseases, including rheumatoid arthritis, type 1 diabetes and celiac disease; all autoimmune diseases with pre-existing treatments.
This discovery, therefore, is expected to lead to effective clinical trials.
Dr. Christiano said: “Finally, we have the possibility of developing drugs that specifically target the mechanism behind the disease.”
Vicki Kalabokes, president and CEO of the National Alopecia Areata Foundation, said: “This research is very exciting as alopecia areata affects a huge number of people worldwide, and there are very few treatments for it-resulting in an enormous unmet medical need. Hair loss creates daily life issues, especially for children who experience social stigma. It affects their quality of life and can lead to long-term psychosocial impact.”
Contributing to the emotional impact of alopecia areata is the nature of the disease itself. Alopecia areata is a cyclical disease having bald patches appear and, in most cases grow back, only to appear again. In many instances, the bald patches can progress to a more extreme, yet rare, form of the disease, alopecia totalis which is total scalp hair loss or alopecia universalis, resulting in the total loss of all body hair.
Included in Dr. Christiano’s discovery, however, is the ability to now predict with accuracy the progression of the disease in a patient. Using the number of genes associated with disease as the marker, a genetic test has been created that can indicate the severity of disease. For the patient, this means that one will be able to determine the likelihood of their bald patch progressing to complete body hair loss. ‘
The study appears in the journal Nature. (ANI)
- Genetic discovery could lead to baldness cure - Jul 02, 2010
- Scientists identify new gene in hair loss - Apr 15, 2010
- Bald Miss Delaware to take part in Miss America beauty pageant - Jan 06, 2011
- Newly crowned Miss Delaware Kayla Martell thinks that 'Bald is beautiful' - Jun 29, 2010
- Eye colour linked to severity of skin conditions - May 07, 2012
- Scarring hair loss in African-American women attributed to hairstyles - Apr 12, 2011
- Hope for balding men - Mar 22, 2012
- New study focuses on cause of celiac disease - Feb 10, 2011
- Study backs gluten-free diet in potential celiac disease patients - Dec 16, 2010
- Housewife works out recipe for regrowing hair - Jan 18, 2011
- Defects in immune system enzyme 'raise arthritis, diabetes risk' - Jun 17, 2010
- Having "dream hair" could lead to baldness - Mar 18, 2010
- Function of novel molecule that underlies human deafness revealed - Jan 22, 2011
- Newly crowned Miss Delaware Kayla Martell is bald - Jun 28, 2010
- Newly Crowned 'Miss Delaware' is Bald, Bold, and Beautiful - Jun 28, 2010
Tags: advisory council member, alopecia areata foundation, alopecia universalis, american researchers, autoimmune diseases, bald patches, columbia university medical, loss of hair, national alopecia areata, national alopecia areata foundation, psychosocial impact, research america, rheumatoid arthritis, scalp hair loss, scientific advisory council, social stigma, totalis, type 1 diabetes, university medical center, unmet medical need