Boffins develop model that demonstrates infectious cause of asthmaMay 25th, 2010 - 1:23 pm ICT by ANI
Washington, May 25 (ANI): An animal model that shows how an early childhood lung infection can cause asthma later in life has been developed by scientists from the University of Massachusetts.
The boffins present their data at the 110th General Meeting of the American Society for Microbiology in San Diego.
Asthma is the most common chronic respiratory disease affecting young children all over the world and the number of new pediatric asthma cases has dramatically increased over the last 20 years. Chlamydia infection of the respiratory tract has been identified as a risk factor in asthma development.
“Even with this knowledge, we currently do not understand how this pathogen causes asthma symptoms and if it really initiates the disease,” says Katir Patel, one of the researchers on the study. “In our mouse model we are able to demonstrate that when mice are infected very early in life with respiratory chlamydia, asthma was induced.”
The key appears to be an altered immune response in neonatal mice. Patel and colleagues began the study by inducing chlamydial lung infection in newborn neonatal as well as in adult mice and compared the immune response and outcomes. The immune response in the newborns was significantly different from adults and the newborns never cleared the infection, while the adults did.
“When allergic airway disease was induced in this mouse model, infected neonatal mice significantly increased their production of allergic type chemical messengers characteristic of asthma, compared to uninfected neonatal controls and infected adult groups,” says Patel.
“Our data indicate that early-life infections with chlamydia may drive aberrant immune responses ultimately causing chronic infection and inducing asthma disease,” says Patel. “Early life respiratory colonization with chlamydia elicits pathogen-specific IgE antibody production, which for the first time provides evidence of an infectious asthma phenotype.” (ANI)
- Antibiotic regimen found effective for Chlamydia-induced reactive arthritis - Apr 29, 2010
- Low-calorie diet tied to bowel disease deaths - Mar 21, 2012
- Doggy dust protects against respiratory infection: Study - Jun 25, 2012
- Tick bite turns red meat into nasty allergy - Jul 25, 2012
- New therapeutic target for asthma, other lung disorders identified - Apr 18, 2011
- Kids with severe asthma at increased risk of developing COPD as adults - May 17, 2010
- New method detects lung infection in 500-year-old mummy - Jul 26, 2012
- Exposure to dirt in childhood promotes immunity - Mar 26, 2012
- Why does flu trigger asthma? - May 30, 2011
- Can flu infections prevent asthma? - Dec 14, 2010
- Over cleanliness could wreck immune system! - Mar 23, 2012
- Key mechanism of childhood respiratory disease identified - Mar 08, 2011
- Boffins come closer to understanding how cystic fibrosis causes lung disease - Apr 29, 2010
- New way to halt lung inflammation in animal models discovered - Jan 15, 2011
- Poor Vit D levels in newborns up risk of respiratory infections - Dec 27, 2010
Tags: adult groups, adult mice, airway disease, altered immune response, american society for microbiology, animal model, antibody production, asthma cases, asthma symptoms, cause of asthma, chemical messengers, chlamydia, chronic infection, chronic respiratory disease, infectious cause, katir, lung infection, mouse model, pediatric asthma, university of massachusetts