Aspirin may prevent paracetamol overdose-induced liver damage

January 27th, 2009 - 11:44 am ICT by ANI  

Washington, January 27 (ANI): Yale University researchers say that aspirin can protect against liver damage induced by overdoses of acetaminophen, also known as paracetamol.
The researchers came to this conclusion following a study on mice, which they claim cast new light on the mechanisms whereby acetaminophen causes liver damage.
They said that aspirin was found to prevent the mice against toxic effects of acetaminophen during the study.
The team have found that overdoses of acetaminophen cause two waves of liver damage: the first wave of liver cell destruction is a result of the toxic nature of acetaminophen, while the second wave is mediated by molecules of the immune system, which is activated in response to the initial acetaminophen-induced liver damage.
In the study, the first wave of dying mouse liver cells were found to promote the production of immune molecules known as proinflammatory cytokines by sinusoidal endothelial cells in the liver.
The production of proinflammatory cytokines required two signalling pathways to be active, one initiated by the protein Tlr9 and one activated by a protein complex known as the Nalp3 inflammasome.
According to the researchers, aspirin seemed to protect the experimental mice against acetaminophen-induced liver damage by downregulating proinflammatory cytokine production. (ANI)

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