Anti-inflammatory drugs reduce effectiveness of antidepressants
April 26th, 2011 - 4:28 pm ICT by ANIThese medicines taken for depression, obsessive-compulsive disorder and anxiety disorders
include ibuprofen, aspirin and naproxen.
The study was conducted by scientists at the Fisher Center for Alzheimer’s Disease Research at
The Rockefeller University, led by Paul Greengard and Jennifer Warner Schmidt.
“The mechanism underlying these effects is not yet clear. Nevertheless, our results may have
profound implications for patients, given the very high treatment resistance rates for depressed
individuals taking SSRIs,” says Dr. Warner-Schmidt.
This surprising discovery, to some extent, explains why so many depressed patients taking SSRIs
do not respond to antidepressant treatment.
The study may hold valid in the case of Alzheimer’s disease. Patients with Alzheimer’s commonly
suffer from depression and unless this can be treated successfully, the illness is likely to grow
severe.
Going further, the study shows that depression in the elderly is also a risk factor for developing
Alzheimer’s disease. The researchers suggest that treating them in time might reduce the risk of
developing the disease.
“Many elderly individuals suffering from depression also have arthritic or related diseases and as a
consequence are taking both antidepressant and anti-inflammatory medications. Our results
suggest that physicians should carefully balance the advantages and disadvantages of continuing
anti-inflammatory therapy in patients being treated with antidepressant medications,” Dr.
Greengard said.
The study has shown that out of the total patients tested, 54 pc responded to the antidepressant in
the absence of any anti-inflammatory medicines compared to approximately, 40 pc of those who
had consumed anti-inflammatory agents.
The study has been published online in the Proceedings of the National Academy of Sciences.
(ANI)
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