1918 influenza pandemic survivors may have developed lifetime immunity

August 18th, 2008 - 1:53 pm ICT by ANI  

London, Aug 18 (ANI): People who survived through 1918 influenza pandemic may have developed immunity to the virus behind it for the rest of their lives, according to a new study.

The findings attain significance as they may offer a new approach to battle future epidemics, say researchers at Mount Sinai School of Medicine.

During a study on mice, the researchers found that the antibodies derived from the B cells of 1918 influenza pandemic survivors served as an effective therapy to against the infection.

Dr. Osvaldo Martinez, post-doctoral fellow at Mount Sinai School of Medicine, believes that the fact that one can isolate these B cells so long after infection will hopefully provide the impetus to further study the mechanisms behind long lived immunity.

For the analysis, Dr. Eric Altschuler at the University of Medicine and Dentistry of New Jersey looked at 32 pandemic survivors.

The subjects were asked to donate blood, which was further tested in the lab for antibodies.

Dr. James Crowe and colleagues at Vanderbilt University produced antibodies from the subjects blood cells, and provided them to Dr. Basleras lab, where the potent neutralizing activity against 1918 virus was demonstrated.

Antibodies were also provided to Dr. Terrence Tumpey at the CDC to test in mice the strength of the antibodies derived from the 1918 survivors.

Our findings show that survivors of the pandemic have highly effective, virus neutralizing antibodies to this powerful virus, and humans can sustain circulating B memory cells to viruses for up to 9 decades after exposure, Nature magazine quoted Dr. Tshidi Tsibane, post-doctoral fellow, Department of Microbiology, Mount Sinai School of Medicine, as saying. (ANI)

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