Now, a potential HIV-test equivalent for early detection of lung cancerSeptember 16th, 2008 - 6:17 pm ICT by ANI
Washington, Sept 16 (ANI): A team of researchers led by Fred Hutchinson Cancer Research Center has confirmed the efficacy of a potential HIV-test equivalent for the early detection of lung cancer.
The test relies on immune-system signals, much like an HIV test. It can detect the presence of lung cancer a year prior to diagnosis, long before symptoms appear.
Samir M. Hanash, M.D., Ph.D., and colleagues at the Hutchinson Center and University of Michigan found that just as the immune system reacts to the presence of HIV by producing an antibody response, which indicates a person is HIV positive, it also mounts a response against specific antigens, or proteins, produced by cancerous lung tumours in their early stages of development.
This kind of immune response wont necessarily kill the tumour, but it can act as a canary in a coal mine, signaling lung cancer at an early stage, before actual symptoms emerge. It is an important step toward developing a biomarker-based blood test for the early detection of lung cancer, said Hanash, head of the Molecular Diagnostic Program in the Public Health Sciences Division at the Hutchinson Center.
The validation study tested the sensitivity and specificity of three biomarkers linked to early stage, pre-symptomatic disease: two previously identified antigens, known as annexin1 and 14-3-3 theta; as well as a newly identified lung-cancer antigen called LAMR1.
For the study, the researchers conducted a blinded analysis of blood samples from 85 current or former smokers collected within a year of lung-cancer diagnosis and blood samples from 85 current or former smokers who did not go on to develop lung cancer.
When combined, the sensitivity of the three-biomarker panel was 51 percent, meaning that autoantibodies to these antigens were present in the blood of more than half of the people who later developed lung cancer.
The specificity, or false-positive, rate of the biomarker panel was 18 percent, meaning that about one-fifth of the comparison group tested positive for the autoantibodies, even though they did not develop the disease.
The fact that we got a signal like this with just three biomarkers is very significant. If we can enlarge this panel by adding a few more, we could develop a blood test with sufficient sensitivity and specificity for detecting lung cancer much earlier than current screening methods allow, Hanash said.
The initial goal is to use such a blood test in conjunction with imaging techniques, such as CT scans, to improve the early detection of lung cancer in those at high risk. Hanash envisions such a test could be in clinical use within five years.
The study is published online in the Journal of Clinical Oncology. (ANI)
- Protein biomarkers in exhaled air to help detect lung cancer early - Feb 03, 2011
- Novel non-invasive tests could help in early detection of cancer - May 04, 2011
- Simple blood test could provide early detection of emphysema - Mar 12, 2011
- Breakthrough can boost lab test's sensitivity - Jun 04, 2012
- Powerful biomarker panel for early detection of breast cancer discovered - Dec 17, 2010
- New protein analysis technique may help in early diagnosis of lung cancer - Dec 03, 2010
- Early warning signs for prostate cancer identified - Nov 07, 2010
- Blood protein in lung cancer may help improve diagnosis, treatment - Mar 03, 2011
- Potential new method for early lung cancer detection - Oct 06, 2010
- Cheek swab may spot lung cancer - Oct 08, 2010
- Chandigarh lab, northeast varsity work on cancer detector - Dec 01, 2011
- Groundbreaking technology to detect Alzheimer's developed - Jan 07, 2011
- How cigarette smoke affects smokers - Apr 07, 2011
- Electronic Nose can sniff tuberculosis - Nov 06, 2011
- New device can detect infectious disease quickly - Mar 01, 2012
Tags: antibody response, biomark, canary in a coal mine, cancer research center, cancerous lung, early detection of lung cancer, fred hutchinson cancer, fred hutchinson cancer research, fred hutchinson cancer research center, hanash, health sciences division, hiv test, hutchinson cancer research center, hutchinson center, lung cancer diagnosis, public health sciences, sensitivity and specificity, symptomatic disease, system signals, validation study