Umbilical cord blood cell transplants may harbour Lou Gehrig’s cureJune 25th, 2008 - 3:53 pm ICT by ANI
Washington, June 25 (ANI): Researchers from University of South Florida have revealed that umbilical cord blood cells transplants may offer a treatment for patients with Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease.
Lou Gehrig’s disease is a progressive, usually fatal, neurodegenerative disease caused by the degeneration of motor neurons. It is the disorder that causes muscle weakness, atrophy throughout the body and respiratory failure three to five years after diagnosis.
During the study, researchers transplanted human umbilical cord blood (HUCB) cells into mouse models with ALS.
Cells were transplanted at three different dose strength levels — low, moderate and high — to determine the degree to which dose levels of transplanted cells might delay disease symptom progression and increase lifespan.
They found that the moderate-strength dose of HUCB cells was most effective in increasing lifespan and reducing disease progression.
“Our results demonstrate that treatment for ALS with an appropriate dose of mononuclear HUBC cells may provide a neuroprotective effect for motor neurons through active involvement of these cells in modulating the host immune inflammatory system response,” said Svitlana Garbuzova-Davis, the study’s lead author from the Centre of Excellence for Aging and Brain Repair at USF.
The research team said that modulating immune and inflammatory effectors with HUCB cells could have a protective effect on dying motor neurons.
However, the researchers said that the mechanism underlying the beneficial effect of hUBC cells for repairing diseased motor neurons in ALS still needs more clarification.
“Future studies should look at multiple injections of smaller doses over time, in order to help translate this research to clinical trials,” said co-author Paul R. Sanberg, PhD, DSc, director of the Centre.
The results are published online at PloS ONE (Public Library of Science).
- New study offers hope to those with Alzheimer's, ALS - Mar 08, 2011
- Human umbilical cord blood cells boost survival, maturation of key brain cells - Dec 15, 2010
- Blue-green algae used for treating Lou Gehrig's disease in mice model - Dec 22, 2010
- Human umbilical cord blood cells boost lab animal's recovery after stroke - Aug 25, 2010
- Mysterious cells may play role in Lou Gehrig's disease - Nov 18, 2010
- Transplanted stem cells form proper brain connections in newborn mice - Jan 20, 2010
- New research promises treatment for swallowing disorders - Apr 29, 2010
- Potential drug candidate for slowing Lou Gehrig's disease progression identified - Oct 20, 2009
- Umbilical cord cells may be useful in arthritis treatment - Nov 16, 2010
- Lead paradox could lead to new therapy for Lou Gehrig's disease - Dec 01, 2009
- Single gene acts as 'master organizer' of motor neurons in spinal cord - Sep 09, 2010
- Early umbilical cord clamping may interrupt 'nature's first stem cell transplant' - May 25, 2010
- New discovery may be the answer to Lou Gehrig's death - Aug 18, 2010
- Umbilical cord blood stem cell transplant may help patients with lung, heart disorders - Nov 24, 2009
- Cell transplants to cure cerebral palsy - Apr 20, 2010
Tags: amyotrophic lateral, blood cells, brain repair, cell transplants, disease progression, disease symptom, dose strength, effectors, fatal neurodegenerative disease, gehrig s disease, human umbilical cord, lateral sclerosis, lou gehrig, moderate strength, mouse models, plos one, respiratory failure, sanberg, strength levels, university of south florida